| The effects of natural pollen exposure on inflammatory cytokines and their relationship with nonspecific bronchial hyperresponsiveness in seasonal allergic rhinitis. | |
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MedLine Citation:
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PMID: 20406594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The exact mechanism of bronchial hyperresponsiveness (BHR) is not clear in allergic rhinitis (AR); an increase of BHR in pollen season suggests that natural pollen exposure causes airway inflammation in seasonal AR (SAR). This study was designed to investigate the effects of natural pollen exposure on inflammatory cytokines and their relationship with BHR. Sixty-six SAR patients with grass pollen sensitivity and 26 nonallergic rhinitis (NAR) patients were included. Peripheral blood samples for cytokine levels were taken and a nonspecific bronchial provocation test was performed during pollen season between May and August. The same measurements were repeated off-season between November and February. These measurements were done in NAR patients once. During the pollen season, SAR patients had significantly more increased levels of IL-13 than NAR patients (11.45 +/- 12.54 versus 5.19 +/- 4.02; p = 0.005). Blood eosinophil numbers were higher in those patients with BHR during pollen season than those without BHR (399.0 +/- 255.8 versus 278.9 +/- 193.2 mm(-3); p = 0.046). Blood eosinophil numbers during off-season were not different in those with and without BHR (respectively, 261.4 +/- 202.3 mm(-3) versus 205.9 +/- 116.9 mm(-3); p = 0.53). IL-10 levels were higher in the patients without BHR (n = 28) than those patients with BHR (n = 22) during off-season (8.12 +/- 13.1 versus 3.28 +/- 0.37; p = 0.04). Having higher levels of IL-10 than threshold value was more frequent in SAR patients without BHR than those patients with BHR during off-season (7/28 versus 1/22; chi(2) = 4.34; p = 0.04). IL-10 has a role in the continuation of BHR during off-season in SAR patients. |
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Authors:
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Emel Kurt; Ayse Aktas; Zafer Gulbas; Sinan Erginel; Sertac Arslan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Allergy and asthma proceedings : the official journal of regional and state allergy societies Volume: 31 ISSN: 1539-6304 ISO Abbreviation: Allergy Asthma Proc Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-09-14 Revised Date: 2011-08-12 |
Medline Journal Info:
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Nlm Unique ID: 9603640 Medline TA: Allergy Asthma Proc Country: United States |
Other Details:
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Languages: eng Pagination: 126-31 Citation Subset: IM |
Affiliation:
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Department of Allergy, Faculty of Medicine, Eskisehir Osmangazi University, Turkey. dremelkurt@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, Plant / adverse effects* Bronchial Hyperreactivity* Bronchial Provocation Tests Humans Inflammation Mediators / blood, immunology Interleukin-10 / blood, immunology Interleukin-13 / blood, immunology Male Middle Aged Nasal Obstruction Poaceae Pollen / adverse effects* Rhinitis, Allergic, Seasonal / blood, diagnosis, immunology*, physiopathology* Seasons |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Plant; 0/Inflammation Mediators; 0/Interleukin-13; 130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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