Document Detail

The effects of natural pollen exposure on inflammatory cytokines and their relationship with nonspecific bronchial hyperresponsiveness in seasonal allergic rhinitis.
MedLine Citation:
PMID:  20406594     Owner:  NLM     Status:  MEDLINE    
The exact mechanism of bronchial hyperresponsiveness (BHR) is not clear in allergic rhinitis (AR); an increase of BHR in pollen season suggests that natural pollen exposure causes airway inflammation in seasonal AR (SAR). This study was designed to investigate the effects of natural pollen exposure on inflammatory cytokines and their relationship with BHR. Sixty-six SAR patients with grass pollen sensitivity and 26 nonallergic rhinitis (NAR) patients were included. Peripheral blood samples for cytokine levels were taken and a nonspecific bronchial provocation test was performed during pollen season between May and August. The same measurements were repeated off-season between November and February. These measurements were done in NAR patients once. During the pollen season, SAR patients had significantly more increased levels of IL-13 than NAR patients (11.45 +/- 12.54 versus 5.19 +/- 4.02; p = 0.005). Blood eosinophil numbers were higher in those patients with BHR during pollen season than those without BHR (399.0 +/- 255.8 versus 278.9 +/- 193.2 mm(-3); p = 0.046). Blood eosinophil numbers during off-season were not different in those with and without BHR (respectively, 261.4 +/- 202.3 mm(-3) versus 205.9 +/- 116.9 mm(-3); p = 0.53). IL-10 levels were higher in the patients without BHR (n = 28) than those patients with BHR (n = 22) during off-season (8.12 +/- 13.1 versus 3.28 +/- 0.37; p = 0.04). Having higher levels of IL-10 than threshold value was more frequent in SAR patients without BHR than those patients with BHR during off-season (7/28 versus 1/22; chi(2) = 4.34; p = 0.04). IL-10 has a role in the continuation of BHR during off-season in SAR patients.
Emel Kurt; Ayse Aktas; Zafer Gulbas; Sinan Erginel; Sertac Arslan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergy and asthma proceedings : the official journal of regional and state allergy societies     Volume:  31     ISSN:  1539-6304     ISO Abbreviation:  Allergy Asthma Proc     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-09-14     Revised Date:  2011-08-12    
Medline Journal Info:
Nlm Unique ID:  9603640     Medline TA:  Allergy Asthma Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  126-31     Citation Subset:  IM    
Department of Allergy, Faculty of Medicine, Eskisehir Osmangazi University, Turkey.
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MeSH Terms
Antigens, Plant / adverse effects*
Bronchial Hyperreactivity*
Bronchial Provocation Tests
Inflammation Mediators / blood,  immunology
Interleukin-10 / blood,  immunology
Interleukin-13 / blood,  immunology
Middle Aged
Nasal Obstruction
Pollen / adverse effects*
Rhinitis, Allergic, Seasonal / blood,  diagnosis,  immunology*,  physiopathology*
Reg. No./Substance:
0/Antigens, Plant; 0/Inflammation Mediators; 0/Interleukin-13; 130068-27-8/Interleukin-10

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