Document Detail


The effects of n-3 fatty acid supplementation on bleeding time, plasma fatty acid composition, and in vitro platelet aggregation in cats.
MedLine Citation:
PMID:  7983618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dietary supplementation with fish and fish oils rich in the n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) has been shown to alter eicosanoid metabolism and impair platelet function in several species. As an initial step in evaluating the antithrombotic effect of these n-3 fatty acids in cats, purified EPA and DHA were administered daily to 8 clinically normal cats for 2 months. Platelet function was evaluated biweekly by determining mucosal bleeding time and in vitro platelet aggregation parameters. Plasma fatty acid profiles were obtained before fish oil supplementation and at the termination of the study. In spite of significant increases (P < .0001) in the plasma concentrations of EPA and DHA after n-3 fatty acid supplementation, there were no significant changes in platelet aggregation or bleeding times. Although it is tempting, based on extrapolation of data from other species, to recommend dietary supplementation with fish oil for cats prone to arterial thromboembolism, these results indicate that administration of large doses of purified EPA and DHA once daily does not inhibit platelet function in normal cats and is unlikely to prevent thrombosis in cats with cardiovascular disease. Additional studies are recommended to ascertain whether more frequent administration of these purified n-3 fatty acids or continual feeding of diets high in n-3 fatty acid content will impair platelet function.
Authors:
J M Bright; P S Sullivan; S L Melton; J F Schneider; T P McDonald
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  8     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    1994 Jul-Aug
Date Detail:
Created Date:  1995-01-03     Completed Date:  1995-01-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM    
Affiliation:
Department of Animal Science, University of Tennessee College of Veterinary Medicine, Knoxville 37901-1071.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Bleeding Time / veterinary*
Blood Platelets / drug effects
Cats / blood*
Docosahexaenoic Acids / administration & dosage,  pharmacology*
Eicosapentaenoic Acid / administration & dosage,  pharmacology*
Fatty Acids / blood*
Female
Male
Platelet Aggregation / physiology*
Grant Support
ID/Acronym/Agency:
HC 14637-18/HC/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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