Document Detail

The effects of motilin on periodic myoelectric spike activity in intact and transected canine small intestine.
MedLine Citation:
PMID:  6875943     Owner:  NLM     Status:  MEDLINE    
The effects of motilin infusions on periodic myoelectric spike activity were studied in conscious dogs with an intact small intestine and in dogs with established jejunal Thiry-Vella loops (T-V loops). Myoelectric activity was recorded from chronically implanted electrodes on the intact intestine, the anastomosed intestine and on the jejunal T-V loop. During fasting, migrating myoelectric complexes (m.m.c.s) were present in the intact and anastomosed intestine and in the T-V loop; in the latter, intervals between m.m.c.s were significantly shorter (P less than 0.05). Infusion of motilin induced premature m.m.c.s in the intact and anastomosed intestine, reducing the interval between successive m.m.c.s (P less than 0.05). In contrast, in the T-V loop, motilin significantly reduced the number of m.m.c.s (P less than 0.01) and the interval between two m.m.c.s was prolonged. After an infusion of motilin, the number of m.m.c.s in the intact and anastomosed intestine was significantly reduced (P less than 0.01), with a corresponding increase in the intervals between m.m.c.s; no further changes were observed in the T-V loop. These results demonstrate that m.m.c.s are induced by motilin in the proximal gut, suggesting a humoral mechanism for m.m.c. initiation in this region. In contrast, the genesis of m.m.c.s in jejunal T-V loops is delayed by motilin.
J Pinnington; D L Wingate
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  337     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  471-8     Citation Subset:  IM    
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MeSH Terms
Action Potentials / drug effects
Gastrointestinal Hormones / pharmacology*
Intestine, Small / drug effects*,  physiology
Jejunum / physiology
Motilin / pharmacology*
Muscle, Smooth / physiology
Time Factors
Reg. No./Substance:
0/Gastrointestinal Hormones; 52906-92-0/Motilin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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