Document Detail

The effects of monochromatic illumination on early eye development in rhesus monkeys.
MedLine Citation:
PMID:  24576875     Owner:  NLM     Status:  Publisher    
Purpose: Influence of longitudinal chromatic aberration (LCA) on emmetropization during early eye development has not been studied in primates. We investigated the effects of quasi-monochromatic lighting on refractive development and eye growth in rhesus monkeys. Methods: Infant rhesus monkeys were raised under 1 of 3 lighting conditions for 51 weeks: quasi-monochromatic blue light (peak 455 nm), red light (peak 610 nm) and white light (color temperature 5000 K). All animals underwent biometric measurements using cycloplegic streak retinoscope, keratometry, and A-scan ultrasonography for refraction, corneal power, and axial components, respectively, at designated time-points. Results: At the 51st week, the mean difference in refraction of the white light and blue light groups, compared to that of the red light group, reached 1.71 D and 1.43 D, respectively (both, P< 0.001). Two monkeys in the red light group developed myopia at the 16th week, while the other seven remained hyperopic throughout the experiment. No significant difference in mean refraction was observed between the blue light group and white light group. Conclusions: Illumination from long-wavelength light during early life could be a risk factor for the development of myopia in a small proportion of rhesus monkeys that are sensitive to L-cone stimulation.
Rui Liu; Min Hu; Ji C He; Xingtao Zhou; Jin-Hui Dai; Xiao-Mei Qu; Hong Liu; Renyuan Chu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-27
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  -     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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