Document Detail

The effects of modified ultrafiltration on pulmonary function and transfusion requirements in patients underwent coronary artery bypass graft surgery.
MedLine Citation:
PMID:  20563469     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The inflammatory response after cardiac surgery increases vascular permeability leading to higher mortality and morbidity in the post operative time. The modified ultrafiltration (MUF) had shown benefits on respiratory, and hemodynamic in pediatric patients. This approach in adults is not well established yet. We hypothesize that modified ultrafiltration may improve respiratory, hemodynamic and coagulation function in adults after cardiac surgeries.
METHODS: A prospective randomized study was carried out with 37 patients who underwent coronary artery bypass graft surgery (CABG) were randomized either to MUF (n=20) at the end of bypass or to control (no MUF) (n=17). The anesthesia and ICU team were blinded for the group selection. The MUF were carried out for 15 minutes after the end of bypass. The patients data were taken at beginning of anesthesia, ending of bypass, ending MUF, 24 hours, and 48 hours after surgery. For clinical outcome the pulmonary, hemodynamic and coagulation function were evaluated.
RESULTS: We observed lower drain loss in the MUF group compared to control group after 48 hours (598 +/- 123 ml vs. 848 +/- 455 ml; P=0.04) and required less red blood cells units transfusion compared to control group (0.6 +/- 0.6 units/patient vs.1.6 +/- 1.1 units/patient; P=0.03). The MUF group showed lower airway resistance (9.3 +/- 0.4 cmH2O.L-1s-1 vs. 12.1 +/- 0.8 cmH2O.L-1s-1; P=0.04). There were no deaths in both groups.
CONCLUSION: The MUF reduces post operatory bleeding and red blood cells units transfusion, but with no differences on clinical outcome were observed. The routinely MUF employment was not associated with hemodynamic instability.
Anali Galluce Torina; Orlando Petrucci; Pedro Paulo Martins de Oliveira; Elaine Soraya Barbosa de Oliveira Severino; Karlos Alexandre de Souza Vilarinho; Carlos Fernando Ramos Lavagnoli; Maria Heloisa Blotta; Reinaldo Wilson Vieira
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Revista brasileira de cirurgia cardiovascular : órgão oficial da Sociedade Brasileira de Cirurgia Cardiovascular     Volume:  25     ISSN:  1678-9741     ISO Abbreviation:  Rev Bras Cir Cardiovasc     Publication Date:    2010 Jan-Mar
Date Detail:
Created Date:  2010-06-21     Completed Date:  2010-10-27     Revised Date:  2012-04-02    
Medline Journal Info:
Nlm Unique ID:  9104279     Medline TA:  Rev Bras Cir Cardiovasc     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  59-65     Citation Subset:  IM    
Surgery Department - Heart Surgery Division - Faculdade de Ciências-Médicas Universidade Estadual de Campinas - UNICAMP.
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MeSH Terms
Analysis of Variance
Blood Coagulation / physiology*
Blood Transfusion / statistics & numerical data*
Chi-Square Distribution
Coronary Artery Bypass*
Hemodynamics / physiology*
Hemofiltration / adverse effects*,  methods
Respiratory Mechanics / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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