Document Detail


The effects of minoxidil on pulmonary and systemic hemodynamics in hypertensive man.
MedLine Citation:
PMID:  832355     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pulmonary hypertension has been described as a possible complication of the antihypertensive vasodilator, minoxidil. A prospective study was undertaken in seven severely hypertensive patients refractory to multiple drug therapy. Treatment was initiated with fixed doses of hydrochlorothiazide (100 mg/day) and propranolol (160 mg/day) for a control period. Mean systemic arterial pressure, cardiac output, and pulmonary artery pressure were then compared before and after the addition of acute (5 day) and chronic (2 month) therapy with minoxidil. Mean arterial blood pressure decreased from a control value of 135 mm Hg to a value of 104 mm Hg acutely and 108 mm Hg chronically. Significant increases in mean cardiac output occurred with minoxidil therapy (from 4.2 L/min control to 5.4 L/min acutely and 5.1 L/min chronically) despite concomitant propranolol treatment. Mean pulmonary artery pressure did not increase either acutely or chronically. The data suggest that in patients with normal pulmonary hemodynamics prior to treatment, pulmonary hypertension does not develop during two months of minoxidil therapy.
Authors:
P E Klotman; C E Grim; M H Weinberger; W E Judson
Related Documents :
237415 - Hemodynamic effects of slow and rapid defibrination with defibrizyme, the thrombin-like...
10634995 - Pulmonary hemodynamics: implications for high altitude pulmonary edema (hape). a review.
6767605 - Chronic obstructive pulmonary disease (copd): effects of bronchodilator drugs on normal...
9105985 - Intravenous nicardipine in the treatment of postoperative arterial hypertension.
8568655 - Mechanics of pulsatile transpyloric flow in the pig.
7233465 - In vivo and in vitro studies on the cerebrovascular dilatation induced by diazoxide in ...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  55     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-03-15     Completed Date:  1977-03-15     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  394-400     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects
Cardiac Output / drug effects
Female
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Hypertension / drug therapy*
Hypertension, Renal / drug therapy
Male
Middle Aged
Minoxidil / pharmacology*,  therapeutic use
Pulmonary Circulation / drug effects*
Pyrimidines / pharmacology*
Vascular Resistance / drug effects
Water-Electrolyte Balance / drug effects
Chemical
Reg. No./Substance:
0/Pyrimidines; 38304-91-5/Minoxidil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The relationship between the metabolism of procainamide and sulfamethazine.
Next Document:  XXII. Intractable paroxysmal tachycardias which proved fatal in type A Wolff-Parkinson-White syndrom...