| The effects of minoxidil on pulmonary and systemic hemodynamics in hypertensive man. | |
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MedLine Citation:
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PMID: 832355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary hypertension has been described as a possible complication of the antihypertensive vasodilator, minoxidil. A prospective study was undertaken in seven severely hypertensive patients refractory to multiple drug therapy. Treatment was initiated with fixed doses of hydrochlorothiazide (100 mg/day) and propranolol (160 mg/day) for a control period. Mean systemic arterial pressure, cardiac output, and pulmonary artery pressure were then compared before and after the addition of acute (5 day) and chronic (2 month) therapy with minoxidil. Mean arterial blood pressure decreased from a control value of 135 mm Hg to a value of 104 mm Hg acutely and 108 mm Hg chronically. Significant increases in mean cardiac output occurred with minoxidil therapy (from 4.2 L/min control to 5.4 L/min acutely and 5.1 L/min chronically) despite concomitant propranolol treatment. Mean pulmonary artery pressure did not increase either acutely or chronically. The data suggest that in patients with normal pulmonary hemodynamics prior to treatment, pulmonary hypertension does not develop during two months of minoxidil therapy. |
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Authors:
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P E Klotman; C E Grim; M H Weinberger; W E Judson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 55 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1977 Feb |
Date Detail:
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Created Date: 1977-03-15 Completed Date: 1977-03-15 Revised Date: 2009-10-27 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 394-400 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects Cardiac Output / drug effects Female Heart Rate / drug effects Hemodynamics / drug effects* Humans Hypertension / drug therapy* Hypertension, Renal / drug therapy Male Middle Aged Minoxidil / pharmacology*, therapeutic use Pulmonary Circulation / drug effects* Pyrimidines / pharmacology* Vascular Resistance / drug effects Water-Electrolyte Balance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Pyrimidines; 38304-91-5/Minoxidil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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