| The effects of mild induced hypothermia on the myocardium: a systematic review. | |
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MedLine Citation:
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PMID: 20151956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mild induced hypothermia improves neurological outcome and reduces mortality among initially comatose survivors of out-of-hospital cardiac arrest. Similar pathological processes occur in the heart and the brain, namely ischaemia followed by reperfusion injury. Animal data indicate that mild induced hypothermia results in improved myocardial salvage, reduced infarct size, reduced left ventricular remodelling and better long-term left ventricular function. Several small human studies suggest that infarct size may be reduced by mild induced hypothermia, although this has not reached significance in any human study to date. There are variable reports of harm to the myocardium caused by mild induced hypothermia, including reduced myocardial contractility and cardiac output, electrocardiographic changes and arrhythmias, especially bradycardia. These harmful effects are reversible with rewarming. |
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Authors:
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Fiona E Kelly; J P Nolan |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-02-11 |
Journal Detail:
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Title: Anaesthesia Volume: 65 ISSN: 1365-2044 ISO Abbreviation: Anaesthesia Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-04 Completed Date: 2010-06-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 505-15 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthesia and Intensive Care Medicine, Frenchay Hospital, Bristol, UK. fiona.kelly@doctors.org.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arrhythmias, Cardiac / etiology Heart Arrest / therapy Humans Hypothermia, Induced* / adverse effects Myocardial Infarction / pathology, prevention & control* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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