Document Detail


The effects of meptazinol in comparison with pentazocine, morphine and naloxone in a rat model of anaphylactic shock.
MedLine Citation:
PMID:  3978318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The actions of meptazinol, pentazocine, morphine and naloxone on the cardiovascular changes accompanying anaphylactic shock were evaluated in ovalbumin-sensitized anaesthetized rats. Pretreatment with meptazinol and pentazocine prevented the fall in mean arterial pressure associated with antigen challenge, whereas morphine and naloxone attenuated but did not completely prevent, this change. None of the drugs significantly altered the antigen-induced decreases in heart rate. All the drugs partially reversed the fall in mean arterial pressure when given after antigen challenge although the activity of naloxone was less marked. Pretreatment with reserpine prevented the restoration of blood pressure by all drugs. Additional experiments with meptazinol showed that pretreatment with phentolamine prevented its pressor action. In pithed non-sensitized rats the frequency-pressor response curve to splanchnic stimulation was shifted to the left by meptazinol and shifted to the right by pentazocine, but the changes were small Morphine and naloxone had no significant effects. It was concluded that opioid mixed agonist-antagonists reverse the cardiovascular changes associated with anaphylactic shock. These effects appear to be mediated by facilitation of sympathetic neurotransmission.
Authors:
P M Paciorek; M H Todd; J F Waterfall
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  84     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-05-16     Completed Date:  1985-05-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  469-75     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anaphylaxis / physiopathology*
Animals
Azepines / pharmacology*
Blood Pressure / drug effects
Decerebrate State
Electric Stimulation
Female
Heart Rate / drug effects
Hemodynamics / drug effects*
Meptazinol / pharmacology*
Morphine / pharmacology*
Naloxone / pharmacology*
Pentazocine / pharmacology*
Phentolamine / pharmacology
Rats
Rats, Inbred Strains
Reserpine / pharmacology
Time Factors
Chemical
Reg. No./Substance:
0/Azepines; 359-83-1/Pentazocine; 465-65-6/Naloxone; 50-55-5/Reserpine; 50-60-2/Phentolamine; 54340-58-8/Meptazinol; 57-27-2/Morphine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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