Document Detail

The effects of meptazinol in comparison with pentazocine, morphine and naloxone in a rat model of anaphylactic shock.
MedLine Citation:
PMID:  3978318     Owner:  NLM     Status:  MEDLINE    
The actions of meptazinol, pentazocine, morphine and naloxone on the cardiovascular changes accompanying anaphylactic shock were evaluated in ovalbumin-sensitized anaesthetized rats. Pretreatment with meptazinol and pentazocine prevented the fall in mean arterial pressure associated with antigen challenge, whereas morphine and naloxone attenuated but did not completely prevent, this change. None of the drugs significantly altered the antigen-induced decreases in heart rate. All the drugs partially reversed the fall in mean arterial pressure when given after antigen challenge although the activity of naloxone was less marked. Pretreatment with reserpine prevented the restoration of blood pressure by all drugs. Additional experiments with meptazinol showed that pretreatment with phentolamine prevented its pressor action. In pithed non-sensitized rats the frequency-pressor response curve to splanchnic stimulation was shifted to the left by meptazinol and shifted to the right by pentazocine, but the changes were small Morphine and naloxone had no significant effects. It was concluded that opioid mixed agonist-antagonists reverse the cardiovascular changes associated with anaphylactic shock. These effects appear to be mediated by facilitation of sympathetic neurotransmission.
P M Paciorek; M H Todd; J F Waterfall
Related Documents :
7723238 - A genetic model of malignant phase hypertension in rats.
1552608 - Intracavernous pressure as an experimental index in a rat model for the evaluation of p...
21539528 - The use of a sound-enabled device to measure pressure during insertion of an epidural c...
8261688 - Relationship of the antihypertensive effect of vasopressin withdrawal to sodium excreti...
3330028 - Is nifedipine a suitable first-line treatment for essential hypertension in general pra...
10339108 - Cost effectiveness of intensive treatment of hypertension. based on presentations by do...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  84     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-05-16     Completed Date:  1985-05-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  469-75     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anaphylaxis / physiopathology*
Azepines / pharmacology*
Blood Pressure / drug effects
Decerebrate State
Electric Stimulation
Heart Rate / drug effects
Hemodynamics / drug effects*
Meptazinol / pharmacology*
Morphine / pharmacology*
Naloxone / pharmacology*
Pentazocine / pharmacology*
Phentolamine / pharmacology
Rats, Inbred Strains
Reserpine / pharmacology
Time Factors
Reg. No./Substance:
0/Azepines; 359-83-1/Pentazocine; 465-65-6/Naloxone; 50-55-5/Reserpine; 50-60-2/Phentolamine; 54340-58-8/Meptazinol; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The binding of doxepin to histamine H1-receptors in guinea-pig and rat brain.
Next Document:  Effects of amosulalol on the electrical responses of guinea-pig vascular smooth muscle to adrenocept...