Document Detail

The effects of mental stress and the cold pressure test on flow-mediated vasodilation.
MedLine Citation:
PMID:  11926347     Owner:  NLM     Status:  MEDLINE    
As a stressful lifestyle has been associated with coronary heart disease, this study aim to evaluate how two stressful tests influence endothelial-dependent vasodilation evaluated by flow-mediated dilation (FMD) of the brachial artery. FMD following 5 min of occlusion of the forearm was evaluated in young healthy volunteers with measurements of brachial artery diameter and blood flow (BABF) using ultrasound before and during a mental arithmetic task (MAT), and during cold pressure test (COP). MAT and COP increased blood pressure to a similar degree (18-21 mmHg). The COP induced a significant reduction in FMD compared to the baseline levels (from 9.3 +/- 3.9 to 5.9 +/- 3.2%, p < 0.01), as well as to the MAT, which in itself did not influence FMD (10.1 +/- 5.0%). However, as MAT increased BABF during hyperaemia significantly, the FMD to BABF ratio was significantly reduced by both stress tests (p < 0.05). Time-control experiments showed FMD measurements to be reproducible and that MAT and COP by themselves only marginally affected brachial artery diameter. In conclusion, cold pressure stress induced an impairment in FMD, but no effect was induced by a MAT. However, when FMD was normalized for the degree of hyperaemic blood flow, the driver of the vasodilation in the brachial artery, a reduction in flow-mediated vasodilation was seen during both mental and cold pressure stress.
Lars Lind; Kristina Johansson; Jan Hall
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Blood pressure     Volume:  11     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  2002  
Date Detail:
Created Date:  2002-04-02     Completed Date:  2003-08-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  22-7     Citation Subset:  IM    
Department of Medicine, University Hospital, Uppsala, Sweden.
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MeSH Terms
Blood Flow Velocity / physiology*
Blood Pressure
Brachial Artery / physiology,  ultrastructure
Cold Temperature*
Hyperemia / physiopathology
Problem Solving / physiology*
Vasodilation / physiology*

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