Document Detail


The effects of mefenamic acid on postprandial intestinal carbohydrate metabolism.
MedLine Citation:
PMID:  3094094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of mefenamic acid on the food-induced changes in intestinal carbohydrate metabolism were determined in an attempt to elucidate the mechanism(s) by which inhibition of prostaglandin synthesis enhances the postprandial increases in intestinal blood flow and oxygen consumption. The data show that when the luminal perfusate was changed from saline to a nutrient/bile solution, there was an increase in carbohydrate utilization, which was offset by absorption of glucose from the lumen. Intravenous administration of mefenamic acid significantly increased both carbohydrate absorption and metabolism when food was placed in the lumen. Changes in carbohydrate absorption and metabolism have been shown to play and important role in determining the magnitude of glucose induced changes in intestinal blood flow and oxygen consumption. Therefore, it is possible that the ability of mefenamic acid to enhance significantly the food-induced increases in blood flow and oxygen consumption may be due in part to its effects on intestinal carbohydrate absorption and utilization.
Authors:
R H Gallavan; C C Chou
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Prostaglandins     Volume:  31     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-11-20     Completed Date:  1986-11-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1069-76     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / pharmacology
Animals
Bile / physiology
Blood Flow Velocity / drug effects
Carbohydrate Metabolism*
Carbon Dioxide / blood
Dogs
Eating
Female
Glucose / metabolism
Infusions, Intravenous
Intestinal Absorption / drug effects
Jejunum / blood supply,  drug effects,  metabolism*
Male
Mefenamic Acid / administration & dosage,  pharmacology*
Oxygen / blood
Sodium Chloride / physiology
Time Factors
Grant Support
ID/Acronym/Agency:
HL-15231/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
11128-99-7/Angiotensin II; 124-38-9/Carbon Dioxide; 50-99-7/Glucose; 61-68-7/Mefenamic Acid; 7647-14-5/Sodium Chloride; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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