Document Detail

The effects of media viscosity on hemodynamics in selective arteriography.
MedLine Citation:
PMID:  7076438     Owner:  NLM     Status:  MEDLINE    
Radiographic contrast media used for arteriography are generally more viscous than plasma or blood; however, little consideration is given to the hemodynamic effects of contrast media viscosity. In this study, in vivo and in vitro injection of isotonic solutions of saline and polyvinylpyrrolidone, having viscosities from 0.8 to 26 centipoise, have been made. The results demonstrate that, when the viscous saline reaches the microcirculation, the resistance to flow increases. The viscous saline thus significantly decreases flow immediately after the injection. At that time the pressure in the artery equals aortic pressure, but the local vascular resistance is elevated because of the viscous material present in the arterioles. Viscous contrast media would cause similar hemodynamic changes during and immediately following an injection. The effects of contrast media hypertonicity, however, modify the viscosity-related changes shortly after the contrast media reaches the capillaries.
T W Morris; M A Kern; R W Katzberg
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative radiology     Volume:  17     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:    1982 Jan-Feb
Date Detail:
Created Date:  1982-07-08     Completed Date:  1982-07-08     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  70-6     Citation Subset:  IM    
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MeSH Terms
Carotid Arteries / physiology
Contrast Media*
Coronary Vessels / physiology
Isotonic Solutions
Regional Blood Flow
Renal Artery / physiology
Sodium Chloride
Vascular Resistance
Grant Support
Reg. No./Substance:
0/Contrast Media; 0/Isotonic Solutions; 7647-14-5/Sodium Chloride; 9003-39-8/Povidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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