| The effects of medetomidine on cardiac contractility in autonomically blocked dogs. | |
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MedLine Citation:
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PMID: 7571389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of medetomidine on load-dependent and relatively load-independent indices of left ventricular contractility and hemodynamics were studied in 8 chloralose-anesthetized, autonomic-blocked dogs. Left ventricular contractility was assessed by the maximum rate of increase in pressure (dP/dtmax), the slope of the end-systolic pressure volume relationship (Ees), preload recruitable stroke work (PRSW), and dP/dtmax-end-diastolic volume relation (SdPV). Dogs received 5 or 10 micrograms/kg of medetomidine IV. The dP/dtmax decreased significantly 30 minutes after both doses of medetomidine. The Ees did not change. Both SdPV and PRSW increased 5 minutes after both doses of medetomidine. Mean arterial pressure, left-ventricular end-diastolic and end-systolic pressures, peripheral vascular resistance and effective arterial elastance increased 5 minutes after both doses of medetomidine. Stroke volume, cardiac output, and stroke work decreased 5 minutes after medetomidine administration. End-diastolic volume did not change. End-systolic volume increased but the difference was not significant. Our study suggests that medetomidine increases inotropy and vascular resistance in autonomic-blocked dogs and that both ventricular and vascular responses to pharmacological manipulation must be considered for a complete assessment of the inotropic effects of a drug. |
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Authors:
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H S de Morais; W W Muir |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Veterinary surgery : VS Volume: 24 ISSN: 0161-3499 ISO Abbreviation: Vet Surg Publication Date: 1995 Jul-Aug |
Date Detail:
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Created Date: 1995-11-21 Completed Date: 1995-11-21 Revised Date: 2011-04-25 |
Medline Journal Info:
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Nlm Unique ID: 8113214 Medline TA: Vet Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 356-64 Citation Subset: IM |
Affiliation:
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Departamento de Clínicas Veterinárias, Universidade Estadual de Londrina, Paraná, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology* Anesthesia / veterinary Anesthetics, Intravenous / administration & dosage Animals Atropine Autonomic Nerve Block* Blood Pressure / drug effects, physiology Cardiac Output / drug effects, physiology Chloralose / administration & dosage Dogs / physiology* Heart / drug effects*, innervation Heart Ventricles / drug effects Imidazoles / pharmacology* Male Medetomidine Myocardial Contraction / drug effects*, physiology Parasympatholytics Random Allocation Stroke Volume / drug effects, physiology Vascular Resistance / drug effects, physiology Ventricular Function |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Anesthetics, Intravenous; 0/Imidazoles; 0/Parasympatholytics; 15879-93-3/Chloralose; 51-55-8/Atropine; 86347-14-0/Medetomidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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