Document Detail


The effects of medetomidine on cardiac contractility in autonomically blocked dogs.
MedLine Citation:
PMID:  7571389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of medetomidine on load-dependent and relatively load-independent indices of left ventricular contractility and hemodynamics were studied in 8 chloralose-anesthetized, autonomic-blocked dogs. Left ventricular contractility was assessed by the maximum rate of increase in pressure (dP/dtmax), the slope of the end-systolic pressure volume relationship (Ees), preload recruitable stroke work (PRSW), and dP/dtmax-end-diastolic volume relation (SdPV). Dogs received 5 or 10 micrograms/kg of medetomidine IV. The dP/dtmax decreased significantly 30 minutes after both doses of medetomidine. The Ees did not change. Both SdPV and PRSW increased 5 minutes after both doses of medetomidine. Mean arterial pressure, left-ventricular end-diastolic and end-systolic pressures, peripheral vascular resistance and effective arterial elastance increased 5 minutes after both doses of medetomidine. Stroke volume, cardiac output, and stroke work decreased 5 minutes after medetomidine administration. End-diastolic volume did not change. End-systolic volume increased but the difference was not significant. Our study suggests that medetomidine increases inotropy and vascular resistance in autonomic-blocked dogs and that both ventricular and vascular responses to pharmacological manipulation must be considered for a complete assessment of the inotropic effects of a drug.
Authors:
H S de Morais; W W Muir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary surgery : VS     Volume:  24     ISSN:  0161-3499     ISO Abbreviation:  Vet Surg     Publication Date:    1995 Jul-Aug
Date Detail:
Created Date:  1995-11-21     Completed Date:  1995-11-21     Revised Date:  2011-04-25    
Medline Journal Info:
Nlm Unique ID:  8113214     Medline TA:  Vet Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  356-64     Citation Subset:  IM    
Affiliation:
Departamento de Clínicas Veterinárias, Universidade Estadual de Londrina, Paraná, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / pharmacology*
Anesthesia / veterinary
Anesthetics, Intravenous / administration & dosage
Animals
Atropine
Autonomic Nerve Block*
Blood Pressure / drug effects,  physiology
Cardiac Output / drug effects,  physiology
Chloralose / administration & dosage
Dogs / physiology*
Heart / drug effects*,  innervation
Heart Ventricles / drug effects
Imidazoles / pharmacology*
Male
Medetomidine
Myocardial Contraction / drug effects*,  physiology
Parasympatholytics
Random Allocation
Stroke Volume / drug effects,  physiology
Vascular Resistance / drug effects,  physiology
Ventricular Function
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Anesthetics, Intravenous; 0/Imidazoles; 0/Parasympatholytics; 15879-93-3/Chloralose; 51-55-8/Atropine; 86347-14-0/Medetomidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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