Document Detail

The effects of meclofenamate, captopril and phentolamine on organ blood flow in the conscious rabbit.
MedLine Citation:
PMID:  7018814     Owner:  NLM     Status:  MEDLINE    
1. Systemic and regional vascular changes were measured in conscious rabbits after intravenous sodium meclofenamate, captopril and phentolamine. These drugs were used respectively to inhibit prostaglandin synthesis and angiotensin-converting enzyme, and to block alpha-adrenoceptors. 2. Meclofenamate reduced renal and adrenal blood flow by 11 and 28% respectively, and doubled hepatic artery flow. The effect on renal and adrenal flow persisted in the presence of phentolamine. 3. Captopril decreased estimated peripheral resistance and increased cardiac output without changing arterial pressure. Kidney and adrenal flow increased by 70 and 21% respectively. 4. Phentolamine reduced arterial pressure and doubled flow to skeletal muscle and increased hepatic artery flow to the liver. 5. Splenic blood flow was unaffected by meclofenamate, captopril or phentolamine alone. Meclofenamate given after captopril caused a halving of splenic flow and a rise in arterial pressure; these effects were prevented by phentolamine. 6. The results point to a continuing effect of prostaglandin synthesis in maintaining blood flow to the kidney and adrenal gland independent of alpha-adrenoceptor activation in resting conscious rabbits. An important modulating effect of prostaglandins on sympathetic vascular tone in the spleen is suggested.
R A Banks; L J Beilin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  61     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-09-22     Completed Date:  1981-09-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  97-105     Citation Subset:  IM    
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MeSH Terms
Adrenal Glands / blood supply
Anthranilic Acids / pharmacology*
Captopril / pharmacology*
Hemodynamics / drug effects
Kidney / blood supply
Liver / blood supply
Meclofenamic Acid / pharmacology*
Phentolamine / pharmacology*
Proline / analogs & derivatives*
Regional Blood Flow / drug effects
Spleen / blood supply
Reg. No./Substance:
0/Anthranilic Acids; 147-85-3/Proline; 50-60-2/Phentolamine; 62571-86-2/Captopril; 644-62-2/Meclofenamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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