Document Detail


The effects of maternal nutrition and body condition on placental and foetal growth in the ewe.
MedLine Citation:
PMID:  12566251     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated the effects of maternal body condition and nutrition on placental and foetal growth in mid-gestation. Welsh Mountain ewes (n=24) of body condition 3.5 (high, H) and 2.0 (low, L) at mating, were fed either 100 per cent or 70 per cent of their daily maintenance requirements from day 22 of gestation, yielding four groups: H100 (n=5), H70 (n=6), L100 (n=7) and L70 (n=6). On day 65, placental and foetal parameters were measured. Whilst the placentome number tended to be lower in L than H ewes, the mean placentome weight was significantly greater in L100 than H100 animals. Nutritionally related changes in IGFBP expression within the placentome and intercotyledonary endometrium may explain these findings, with IGFBP-3 expression in the luminal epithelium and caruncular stroma of the placentome villi being inversely correlated to placentome number and the total placentome weight respectively. The foetal CRL was shorter and the ponderal index greater in L than H ewes. The foetal CRL was positively correlated to maternal IGF-I concentrations and the placentome number, although the foetal weight remained unaltered by treatment. This study therefore demonstrates that body condition and ration can alter foetal and placental growth, perhaps by modifying systemic parameters and uterine IGF expression.
Authors:
J C Osgerby; T S Gadd; D C Wathes
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Placenta     Volume:  24     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    2003 Feb-Mar
Date Detail:
Created Date:  2003-02-04     Completed Date:  2003-07-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  236-47     Citation Subset:  IM    
Affiliation:
Department of Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Constitution / physiology*
Crown-Rump Length
DNA Primers / chemistry
Embryonic and Fetal Development / physiology*
Enzyme-Linked Immunosorbent Assay
Female
Food Deprivation / physiology*
Gestational Age
Glycoproteins / genetics,  metabolism
In Situ Hybridization
Insulin / blood
Insulin-Like Growth Factor Binding Proteins / genetics,  metabolism
Maternal Nutritional Physiological Phenomena / physiology*
Oligonucleotides, Antisense / chemistry
Organ Size
Placenta / growth & development*,  metabolism
Pregnancy
Pregnancy, Animal / blood
RNA, Messenger / metabolism
Serpins*
Sheep
Chemical
Reg. No./Substance:
0/DNA Primers; 0/Glycoproteins; 0/Insulin-Like Growth Factor Binding Proteins; 0/Oligonucleotides, Antisense; 0/RNA, Messenger; 0/Serpins; 0/uterine luminal fluid proteins; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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