Document Detail

The effects of maternal nutrition around the time of conception on the health of the offspring.
MedLine Citation:
PMID:  17491161     Owner:  NLM     Status:  MEDLINE    
The incidence of prematurity, diabetes and cardiovascular disease have been increasing in both the developed and developing world. Increasing numbers of human studies suggest that these serious health outcomes may have developmental origins originating from nutritional deficits in the periconceptional period, with maternal nutrition around the time of conception now shown to have important effects on the length of gestation, trajectory of fetal growth and on postnatal growth and health. Biomedical research using the pregnant sheep has been widely employed to gain a deeper understanding of the underlying mechanisms involved. There is growing awareness that this field of research has major implications for the livestock production industry. From our own studies on sheep we have evidence that maternal undernutrition during the periconceptional period results in altered fetal hypothalamic-pituitary-adrenal axis (HPAA) development, an increased rate of premature birth, altered fetal pancreatic function, insulin signalling and amino acid metabolism, and also alterations in maternal adaptation to pregnancy. We are currently studying the postnatal consequences of these changes. Other research groups have shown that restricted nutrition of sheep in the early part of pregnancy alters postnatal muscle development, fat deposition, cardiovascular regulation and HPAA function. One aim of this review is to illustrate how biomedical research using animals such as the sheep has been used to gain a better understanding of the consequences of reduced maternal nutrition during the periconceptional period. We suggest that there are equally important consequences of this research for the livestock production industries.
M H Oliver; A L Jaquiery; F H Bloomfield; J E Harding
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Society of Reproduction and Fertility supplement     Volume:  64     ISSN:  1747-3403     ISO Abbreviation:  Soc Reprod Fertil Suppl     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-11     Completed Date:  2007-11-05     Revised Date:  2014-06-13    
Medline Journal Info:
Nlm Unique ID:  101295315     Medline TA:  Soc Reprod Fertil Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  397-410     Citation Subset:  IM    
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MeSH Terms
Birth Weight
Cardiovascular Diseases / embryology
Fertilization / physiology*
Fetal Development / physiology*
Models, Animal
Obesity / embryology
Prenatal Nutritional Physiological Phenomena*

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