Document Detail


The effects of maternal diabetes on placental transfer of essential and non-essential fatty acids in the rat.
MedLine Citation:
PMID:  2132200     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies were performed on the transfer of essential and non-essential non-esterified fatty acids across the in-situ perfused placenta in normal and diabetic rats in late gestation. Results indicated that increasing maternal glycaemia is associated with a decrease in the unidirectional transfer of both essential and non-essential fatty acids. This reduced transfer is dependent upon the uteroplacental blood flow, which is compromised in the diabetic animals. The transfer of essential fatty acid was always twofold that of non-essential fatty acids regardless of the total amount of lipid transferred, indicating a selective mechanism for the transfer of these moieties.
Authors:
M Honda; C Lowy; C R Thomas
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes research (Edinburgh, Scotland)     Volume:  15     ISSN:  0265-5985     ISO Abbreviation:  Diabetes Res.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1992-01-09     Completed Date:  1992-01-09     Revised Date:  2007-09-11    
Medline Journal Info:
Nlm Unique ID:  8502339     Medline TA:  Diabetes Res     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  47-51     Citation Subset:  IM    
Affiliation:
Division of Medicine, U.M.D.S., St. Thomas' Hospital, London.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / analysis
Carbon Dioxide / blood
Diabetes Mellitus, Experimental / physiopathology*
Fatty Acids, Essential / metabolism*
Fatty Acids, Nonesterified / metabolism*
Female
Fetus / physiology
Hemoglobins / analysis
Male
Maternal-Fetal Exchange*
Oxygen / blood
Partial Pressure
Placenta / physiopathology*
Pregnancy
Pregnancy in Diabetics / physiopathology*
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Essential; 0/Fatty Acids, Nonesterified; 0/Hemoglobins; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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