Document Detail


The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task.
MedLine Citation:
PMID:  17126859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Schizophrenia is characterized by attentional deficits possibly associated with glutamate dysfunction. The role of postsynaptic metabotropic glutamate 5 receptors (mGluR5) or presynaptic inhibitory mGluR2/3 on attention is currently unknown. We investigated the effects of the mGluR5 antagonist MPEP (2-methyl-6[phenylethynyl]-pyridine) and the mGluR2/3 antagonist LY341495 on attention in the 5-choice serial reaction time task (5CSRTT), as well as on food intake to evaluate their effects on food motivation. The effects of pre-feeding and the muscle relaxant curare were examined to characterize the effects of alterations in the motivation or ability to perform the task, respectively. MPEP had no effect on accuracy but overall decreased performance in the 5CSRTT, including decreased speed of responding and decreased premature responses. LY341495 had no significant effect on rats' performance in the 5CSRTT. LY341495 decreased food intake in the home cage to a greater extent than MPEP. Curare decreased the speed of correct responding, reflecting motor impairment. Free feeding decreased overall performance, number of trials completed and number of head entries into the feeder, reflecting decreased motivation to perform the task. Thus, blockade of mGluR5, but not mGluR2/3, decreased overall responding without affecting accuracy in the 5CSRTT.
Authors:
Svetlana Semenova; Athina Markou
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2006-11-28
Journal Detail:
Title:  Neuropharmacology     Volume:  52     ISSN:  0028-3908     ISO Abbreviation:  Neuropharmacology     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-16     Completed Date:  2007-05-01     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  863-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / pharmacology*
Analysis of Variance
Animals
Behavior, Animal / drug effects
Choice Behavior / drug effects*
Curare / pharmacology
Dose-Response Relationship, Drug
Excitatory Amino Acid Antagonists / pharmacology*
Male
Nicotinic Antagonists / pharmacology
Pyridines / pharmacology*
Rats
Rats, Wistar
Reaction Time / drug effects*
Xanthenes / pharmacology*
Grant Support
ID/Acronym/Agency:
MH69062/MH/NIMH NIH HHS; R01 MH062527/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/6-methyl-2-(phenylethynyl)pyridine; 0/Amino Acids; 0/Excitatory Amino Acid Antagonists; 0/LY 341495; 0/Nicotinic Antagonists; 0/Pyridines; 0/Xanthenes; 8063-06-7/Curare
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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