Document Detail

The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task.
MedLine Citation:
PMID:  17126859     Owner:  NLM     Status:  MEDLINE    
Schizophrenia is characterized by attentional deficits possibly associated with glutamate dysfunction. The role of postsynaptic metabotropic glutamate 5 receptors (mGluR5) or presynaptic inhibitory mGluR2/3 on attention is currently unknown. We investigated the effects of the mGluR5 antagonist MPEP (2-methyl-6[phenylethynyl]-pyridine) and the mGluR2/3 antagonist LY341495 on attention in the 5-choice serial reaction time task (5CSRTT), as well as on food intake to evaluate their effects on food motivation. The effects of pre-feeding and the muscle relaxant curare were examined to characterize the effects of alterations in the motivation or ability to perform the task, respectively. MPEP had no effect on accuracy but overall decreased performance in the 5CSRTT, including decreased speed of responding and decreased premature responses. LY341495 had no significant effect on rats' performance in the 5CSRTT. LY341495 decreased food intake in the home cage to a greater extent than MPEP. Curare decreased the speed of correct responding, reflecting motor impairment. Free feeding decreased overall performance, number of trials completed and number of head entries into the feeder, reflecting decreased motivation to perform the task. Thus, blockade of mGluR5, but not mGluR2/3, decreased overall responding without affecting accuracy in the 5CSRTT.
Svetlana Semenova; Athina Markou
Related Documents :
432629 - Discrimination learning without short-term memory: dissociation of memory processes in ...
22763449 - The diet of australopithecus sediba.
9768549 - Dissociation of consummatory and vocal components of feeding in squirrel monkeys treate...
2162529 - Do peptide-induced changes in feeding occur because of changes in motivation to eat?
5803539 - Unit activity: motiviation-dependent responses from midbrain neurons.
20554869 - Concurrent glucocorticoid and noradrenergic activity shifts instrumental behavior from ...
14672309 - Solutions exist for constraints to household production and retention of animal food pr...
21736839 - Dietary patterns are associated with cardiometabolic risk factors in a representative s...
7582639 - Worldwide regulations for mycotoxins in 1994.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2006-11-28
Journal Detail:
Title:  Neuropharmacology     Volume:  52     ISSN:  0028-3908     ISO Abbreviation:  Neuropharmacology     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-16     Completed Date:  2007-05-01     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  863-72     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acids / pharmacology*
Analysis of Variance
Behavior, Animal / drug effects
Choice Behavior / drug effects*
Curare / pharmacology
Dose-Response Relationship, Drug
Excitatory Amino Acid Antagonists / pharmacology*
Nicotinic Antagonists / pharmacology
Pyridines / pharmacology*
Rats, Wistar
Reaction Time / drug effects*
Xanthenes / pharmacology*
Grant Support
Reg. No./Substance:
0/6-methyl-2-(phenylethynyl)pyridine; 0/Amino Acids; 0/Excitatory Amino Acid Antagonists; 0/LY 341495; 0/Nicotinic Antagonists; 0/Pyridines; 0/Xanthenes; 8063-06-7/Curare

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The 1974 spill of the Bouchard 65 oil barge: petroleum hydrocarbons persist in Winsor Cove salt mars...
Next Document:  Pharmacological and genetic manipulation of kappa opioid receptors: effects on cocaine- and pentylen...