| The effects of a lupin-enriched diet on oxidative stress and factors influencing vascular function in overweight subjects. | |
| | |
MedLine Citation:
|
PMID: 20214496 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
A diet enriched in lupin kernel flour can lower blood pressure, but mechanisms responsible are unclear. Lupin is a source of polyphenols, protein, and L-arginine, factors that may influence blood pressure via effects on oxidative stress and vascular function. Therefore, we aimed to determine the effects of a lupin-enriched diet on oxidative stress and factors influencing vascular function as potential mechanisms for demonstrated benefits on blood pressure. Overweight men and women (n = 88) were recruited to a 16-week parallel-design study. Participants were randomly assigned to replace 15%-20% of their usual daily energy intake with white bread (control) or lupin kernel flour-enriched bread (lupin). All measurements were taken at baseline and 16 weeks. At baseline, plasma F₂-isoprostanes and 20-hydroxyeicosatetraenoic acid (20-HETE) were positively associated with blood pressure, and plasma nitrite was negatively associated with blood pressure (p < 0.05). For lupin relative to control, the estimated differences in plasma F₂-isoprostanes (45 pmol/L; 95%CI: -68, 158), urinary F₂-isoprostanes (17 pmol/mmol creatinine; 95%CI: -43, 76), plasma 20-HETE (75 pmol/L; 95%CI: -91, 241), and plasma nitrite (-0.3 μmol/L; 95%CI: -1.1, 0.4) were not significant. Although regular consumption of lupin-enriched bread can lower blood pressure, these results do not support for the hypothesis that this is via effects on oxidative stress or vascular function. |
| | |
Authors:
|
Xingbin Yang; Kevin D Croft; Ya P Lee; Trevor A Mori; Ian B Puddey; Sofia Sipsas; Anne Barden; Ewald Swinny; Jonathan M Hodgson |
Related Documents
:
|
2386446 - High +gz centrifuge training: the electrocardiographic response to +gz-induced loss of ... 16940246 - The g protein-coupled receptor kinase 4 gene modulates stress-induced sodium excretion ... 1433316 - The protective role of heat stress in the ischaemic and reperfused rabbit myocardium. 656266 - Standardized stress and hypertension: comparison of effect of propranolol and methyldopa. 22348516 - Seasonal variability and meteorological factors: retrospective study of the incidence o... 6735826 - Noninvasive detection of airway constriction in awake guinea pigs. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Antioxidants & redox signaling Volume: 13 ISSN: 1557-7716 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-07 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
|
Languages: eng Pagination: 1517-24 Citation Subset: IM |
Affiliation:
|
School of Medicine and Pharmacology, University of Western Australia, and the WAIMR Centre for Food and Genomic Medicine, Perth, Western Australia, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antioxidant and anti-inflammatory effects of resveratrol in airway disease.
Next Document: HER2 as a target for breast cancer therapy.