Document Detail

The effects of low to moderate prenatal alcohol exposure in early pregnancy on IQ in 5-year-old children.
MedLine Citation:
PMID:  22712749     Owner:  NLM     Status:  Publisher    
Please cite this paper as: Falgreen Eriksen H, Mortensen E, Kilburn T, Underbjerg M, Bertrand J, Støvring H, Wimberley T, Grove J, Kesmodel U. The effects of low to moderate prenatal alcohol exposure in early pregnancy on IQ in 5-year-old children. BJOG 2012; DOI: 10.1111/j.1471-0528.2012.03394.x. Objective  To examine the effects of low to moderate maternal alcohol consumption during early pregnancy on children's intelligence (IQ) at age 5 years. Design  Prospective follow-up study. Setting  Neuropsychological testing in four Danish cities 2003-2008. Population  A cohort of 1628 women and their children sampled from the Danish National Birth Cohort. Methods  Participants were sampled based on maternal alcohol consumption during pregnancy. At 5 years of age, children were tested with the Wechsler Preschool and Primary Scale of Intelligence-Revised (WPPSI-R). Parental education, maternal IQ, maternal smoking in pregnancy, the child's age at testing, gender, and tester were considered core confounding factors, whereas the full model also controlled for maternal binge drinking, age, BMI, parity, home environment, postnatal smoking in the home, health status, and indicators for hearing and vision impairments. Main outcome measures  The WPPSI-R. Results  No differences in test performance were observed between children whose mothers reported consuming between one and four or between five and eight drinks per week at some point during pregnancy, compared with children of mothers who abstained. For women who reported consuming nine or more drinks per week no differences were observed for mean differences; however, the risks of low full-scale IQ (OR 4.6; 95% CI 1.2-18.2) and low verbal IQ (OR 5.9; 95% CI 1.4-24.9) scores, but not low performance IQ score, were increased. Conclusions  Maternal consumption of low to moderate quantities of alcohol during pregnancy was not associated with the mean IQ score of preschool children. Despite these findings, acceptable levels of alcohol use during pregnancy have not yet been established, and conservative advice for women continues to be to avoid alcohol use during pregnancy.
H-L Falgreen Eriksen; El Mortensen; T Kilburn; M Underbjerg; J Bertrand; H Støvring; T Wimberley; J Grove; Us Kesmodel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-20
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  -     ISSN:  1471-0528     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG.
Department of Public Health, Section of Epidemiology, Aarhus University, Aarhus, Denmark Institute of Public Health and Centre for Healthy Ageing, University of Copenhagen, Copenhagen, Denmark Children's Neurocentre at Vejlefjord Rehabilitation Centre, Vejle, Denmark Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA Department of Public Health, Section of Biostatistics, Aarhus University, Aarhus, Denmark Department of Biomedicine, Faculty of Health Sciences and Bioinformatics Research Centre (BiRC), Aarhus University, Aarhus, Denmark Department of Obstetrics and Gynaecology, Aarhus University Hospital, Aarhus, Denmark.
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