Document Detail


The effects of low to moderate alcohol consumption and binge drinking in early pregnancy on executive function in 5-year-old children.
MedLine Citation:
PMID:  22712874     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the effects of low to moderate maternal alcohol consumption and binge drinking in early pregnancy on children's executive functions at the age of 5 years.
DESIGN: Follow-up study.
SETTING: Neuropsychological testing in four Danish cities 2003-2008. Population A cohort of 1628 women and their children sampled from the Danish National Birth Cohort.
METHODS: Participants were sampled based on maternal alcohol drinking patterns during early pregnancy. When the children were 5 years old, the parent and teacher forms of the Behaviour Rating Inventory of Executive Function (BRIEF) were completed by the mothers and a preschool teacher. Parental education, maternal IQ, prenatal maternal smoking, the child's age at testing, and the child's gender were considered core confounding factors. The full model also included maternal binge drinking or low to moderate alcohol consumption, maternal age, parity, maternal marital status, family home environment, postnatal parental smoking, pre-pregnancy maternal body mass index (BMI), and the health status of the child.
MAIN OUTCOME MEASURES: The BRIEF parent and teacher forms.
RESULTS: Adjusted for all potential confounding factors, no statistically significant associations between maternal low to moderate average weekly consumption and BRIEF index scores were observed.In adjusted analyses, binge drinking in gestational week 9 or later was significantly associated with elevated Behavioural Regulation Index parent Scores (2.04, 95% CI 0.33–3.76), and with the risk of high scores on the Metacognitive Index assessed by the teacher (OR 2.06, 95% CI 1.01–4.23) [corrected].
CONCLUSIONS: This study did not observe significant effects of low to moderate alcohol consumption during pregnancy on executive functioning at the age of 5 years. Furthermore, only weak and no consistent associations between maternal binge drinking and executive functions were observed.
Authors:
Å Skogerbø; U S Kesmodel; T Wimberley; H Støvring; J Bertrand; N I Landrø; E L Mortensen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2012-06-20
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  119     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-13     Completed Date:  2012-10-19     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  1201-10     Citation Subset:  AIM; IM    
Copyright Information:
© 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / epidemiology,  psychology*
Child, Preschool
Denmark / epidemiology
Ethanol / poisoning*
Executive Function*
Female
Follow-Up Studies
Humans
Male
Neuropsychological Tests
Personality Inventory
Pregnancy
Pregnancy Trimester, First
Pregnancy Trimester, Second
Prenatal Exposure Delayed Effects / chemically induced,  epidemiology*
Chemical
Reg. No./Substance:
3K9958V90M/Ethanol
Comments/Corrections
Comment In:
BJOG. 2012 Dec;119(13):1669-70; author reply 1673-5   [PMID:  23164115 ]
BJOG. 2012 Dec;119(13):1670-1; author reply 1673-5   [PMID:  23164116 ]
Erratum In:
BJOG. 2013 Sep;120(10):1302
BJOG. 2012 Dec;119(13):1683

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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