| The effects of a low-dose monophasic preparation of levonorgestrel and ethinyl estradiol on coagulation and other hemostatic factors. | |
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MedLine Citation:
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PMID: 10561678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study was undertaken to evaluate the effects on hemostatic factors of a low-dose preparation of levonorgestrel and ethinyl estradiol in a 12-cycle study. Study Design: Thirty healthy women began taking 100 microg levonorgestrel and 20 microg ethinyl estradiol on the first day of the menstrual cycle, continued to take the preparation for the next 21 days, and then took placebo for 7 days. Mean changes in prothrombin time, partial thromboplastin time, and levels of factors VII and X, antithrombin, plasminogen, fibrinogen, protein S, thrombin-antithrombin complexes, and D-dimer were analyzed at baseline and at cycles 3, 6, and 12 with paired Student t tests. RESULTS: Factor X, plasminogen antigen and activity, and D-dimer levels were significantly increased (P </=.01) during all 3 cycle periods. Antithrombin antigen and protein S total antigen levels were significantly (P </=.001 ) decreased at cycles 3, 6, and 12, whereas factor VII and protein S activity levels were significantly (P </=.05) decreased at cycle 3 and at cycles 3 and 6, respectively. CONCLUSION: The effects on hemostatic factors in healthy women of a monophasic preparation of 100 microg levonorgestrel and 20 microg ethinyl estradiol were similar to those of other low-dose oral contraceptives. |
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Authors:
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D F Archer; E F Mammen; G S Grubb |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 181 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1999 Nov |
Date Detail:
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Created Date: 1999-12-07 Completed Date: 1999-12-07 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 63-6 Citation Subset: AIM; IM |
Affiliation:
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Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk 23507-1627, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antithrombins / analysis Blood Coagulation / drug effects* Blood Coagulation Factors / analysis Contraceptive Agents, Female / administration & dosage*, therapeutic use Contraceptives, Oral, Synthetic / administration & dosage*, therapeutic use Dose-Response Relationship, Drug Drug Combinations Estradiol Congeners / administration & dosage*, therapeutic use Ethinyl Estradiol / administration & dosage*, therapeutic use Female Fibrin Fibrinogen Degradation Products / analysis Hemostasis / drug effects* Humans Levonorgestrel / administration & dosage*, therapeutic use Plasminogen / analysis Protein S / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antithrombins; 0/Blood Coagulation Factors; 0/Contraceptive Agents, Female; 0/Contraceptives, Oral, Synthetic; 0/Drug Combinations; 0/Estradiol Congeners; 0/Fibrin Fibrinogen Degradation Products; 0/Protein S; 0/fibrin fragment D; 57-63-6/Ethinyl Estradiol; 797-63-7/Levonorgestrel; 9001-91-6/Plasminogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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