Document Detail

The effects of a low-dose monophasic preparation of levonorgestrel and ethinyl estradiol on coagulation and other hemostatic factors.
MedLine Citation:
PMID:  10561678     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was undertaken to evaluate the effects on hemostatic factors of a low-dose preparation of levonorgestrel and ethinyl estradiol in a 12-cycle study.
STUDY DESIGN: Thirty healthy women began taking 100 microg levonorgestrel and 20 microg ethinyl estradiol on the first day of the menstrual cycle, continued to take the preparation for the next 21 days, and then took placebo for 7 days. Mean changes in prothrombin time, partial thromboplastin time, and levels of factors VII and X, antithrombin, plasminogen, fibrinogen, protein S, thrombin-antithrombin complexes, and D-dimer were analyzed at baseline and at cycles 3, 6, and 12 with paired Student t tests.
RESULTS: Factor X, plasminogen antigen and activity, and D-dimer levels were significantly increased (P </=.01) during all 3 cycle periods. Antithrombin antigen and protein S total antigen levels were significantly (P </=.001 ) decreased at cycles 3, 6, and 12, whereas factor VII and protein S activity levels were significantly (P </=.05) decreased at cycle 3 and at cycles 3 and 6, respectively.
CONCLUSION: The effects on hemostatic factors in healthy women of a monophasic preparation of 100 microg levonorgestrel and 20 microg ethinyl estradiol were similar to those of other low-dose oral contraceptives.
D F Archer; E F Mammen; G S Grubb
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  181     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-07     Completed Date:  1999-12-07     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  AIM; IM    
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MeSH Terms
Antithrombins / analysis
Blood Coagulation / drug effects*
Blood Coagulation Factors / analysis
Contraceptive Agents, Female / administration & dosage*,  therapeutic use
Contraceptives, Oral, Synthetic / administration & dosage*,  therapeutic use
Dose-Response Relationship, Drug
Drug Combinations
Estradiol Congeners / administration & dosage*,  therapeutic use
Ethinyl Estradiol / administration & dosage*,  therapeutic use
Fibrin Fibrinogen Degradation Products / analysis
Hemostasis / drug effects*
Levonorgestrel / administration & dosage*,  therapeutic use
Plasminogen / analysis
Protein S / analysis
Reg. No./Substance:
0/Antithrombins; 0/Blood Coagulation Factors; 0/Contraceptive Agents, Female; 0/Contraceptives, Oral, Synthetic; 0/Drug Combinations; 0/Estradiol Congeners; 0/Fibrin Fibrinogen Degradation Products; 0/Protein S; 0/fibrin fragment D; 423D2T571U/Ethinyl Estradiol; 5W7SIA7YZW/Levonorgestrel; 9001-91-6/Plasminogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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