Document Detail

The effects of long term feeding of Solanum glaucophyllum to growing rats on Ca, Mg, P and bone metabolism.
MedLine Citation:
PMID:  177152     Owner:  NLM     Status:  MEDLINE    
The effects of the long term ingestion of Solanum Glaucophyllum leaves (SG) by the rat was investigated in two series of experiments; the animals were fed a normal (for 8 weeks) or a low Ca diet (for 5 weeks). With both diets, the intestinal absorption of Ca was increased and the endogenous fecal Ca excretion was decreased by SG treatment. Added to a normal Ca diet, SG increased the urinary excretion of Ca, Mg and P and reduced the excretion of hydroxyproline and pyrophosphate. At the histological level, SG induced a higher rate of bone tissue synthesis on trabecular and endosteal surfaces. The bone content of hydroxyproline and citrate increased significantly. The total alkaline phosphatase activity of plasma decreased as a function of SG intake due to a decreased in the activity of the intestinal isoenzyme, which was not compensated by the increase in the bone isoenzyme activity. The Mg absorption was decreased by SG inducing lower Mg balances and lower plasma Mg levels. Added to a low Ca diet, SG increased the severity of the secondary hyperparathyroidism induced by the diet. The urinary excretion of hydroxyproline and the plasma alkaline phosphatase activity (both isoenzymes) were significantly increased. The Na and K content of bone decreased as a function of SG intake. 45Ca kinetic experiments revealed that SG increased the rate of Ca resorption and the rate constant of the fast exchangeable Ca pool, in both diets.
R C Puche; M E Locatto; J L Ferretti; M C Fernandez; M B Orsatti; J L Valenti
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Calcified tissue research     Volume:  -     ISSN:  0008-0594     ISO Abbreviation:  Calcif Tissue Res     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0114414     Medline TA:  Calcif Tissue Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  105-19     Citation Subset:  IM    
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MeSH Terms
Alkaline Phosphatase / blood
Alkaloids / pharmacology*
Animal Feed
Bone and Bones / metabolism*
Calcium / metabolism*
Calcium, Dietary
Dihydroxycholecalciferols / pharmacology
Diphosphates / urine
Growth / drug effects
Hydroxyproline / metabolism
Hyperparathyroidism, Secondary / chemically induced
Magnesium / metabolism*
Phosphorus / metabolism*
Reg. No./Substance:
0/Alkaloids; 0/Calcium, Dietary; 0/Dihydroxycholecalciferols; 0/Diphosphates; 51-35-4/Hydroxyproline; 7439-95-4/Magnesium; 7440-70-2/Calcium; 7723-14-0/Phosphorus; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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