| The effects of long-term conventional mechanical ventilation on the lungs of adult rats. | |
| | |
MedLine Citation:
|
PMID: 18596632 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Ventilation-induced lung injury is often studied in animal models by using ventilation strategies with high-tidal volumes and high-oxygen concentration over a relatively short period of time. The injury induced by these ventilation strategies includes alterations to the surfactant system and up-regulation of inflammatory markers. Whether these responses to ventilation occur with more clinically relevant ventilation strategies is not known. OBJECTIVE: To assess how healthy adult rats respond to 24 hrs of conventional mechanical ventilation with respect to lung physiology, markers of inflammation, and alterations to pulmonary surfactant, and how this is affected by the oxygen concentration. INTERVENTIONS: Adult rats were mechanically ventilated for 24 hrs with a tidal volume of 8 mL/kg, 5 cm H2O positive end-expiratory pressure, at 60 breaths/min with either 21% or 100% oxygen. Animals were monitored for blood oxygenation and other physiologic parameters. After ventilation, lungs were lavaged and analyzed for inflammatory markers and pulmonary surfactant. These outcomes were compared with measurements obtained from spontaneously breathing rats exposed to either 21% or 100% oxygen for 24 hrs. MAIN RESULTS: Twenty-four hours of ventilation did not result in significant changes in blood oxygenation. Inflammatory markers, such as interleukin-6 concentration and the number of neutrophils in the lavage, were increased in ventilated animals compared with the nonventilated controls, regardless of the level of inspired oxygen. The amount of active surfactant was increased after ventilation; however, the surface activity of this material was impaired as compared with controls. CONCLUSION: Prolonged mechanical ventilation of health lungs with a physiologically benign strategy can contribute to the inflammatory response and cause alterations to pulmonary surfactant. |
| | |
Authors:
|
Timothy C Bailey; Adam A Maruscak; Erica L Martin; Amy R Forbes; Anne Petersen; Lynda A McCaig; Li-Juan Yao; James F Lewis; Ruud A W Veldhuizen |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Critical care medicine Volume: 36 ISSN: 1530-0293 ISO Abbreviation: Crit. Care Med. Publication Date: 2008 Aug |
Date Detail:
|
Created Date: 2008-07-31 Completed Date: 2008-08-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: United States |
Other Details:
|
Languages: eng Pagination: 2381-7 Citation Subset: AIM; IM |
Affiliation:
|
Department of Physiology and Pharmacology, Lawson Health Research Institute, the University of Western Ontario, London, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biological Markers Male Pulmonary Surfactants / metabolism* Rats Rats, Sprague-Dawley Respiration, Artificial / adverse effects* Respiratory Distress Syndrome, Adult / etiology*, metabolism, physiopathology Tidal Volume |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Pulmonary Surfactants |
| Comments/Corrections | |
Comment In:
|
Crit Care Med. 2008 Aug;36(8):2471-3
[PMID:
18664809
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Early intensive care unit mobility therapy in the treatment of acute respiratory failure.
Next Document: Role of nuclear factor-kappaB-dependent induction of cytokines in the regulation of vasopressin V1A-...