Document Detail

The effects of lipids on the immune response of patients with cancer.
MedLine Citation:
PMID:  10936906     Owner:  NLM     Status:  MEDLINE    
The role of diet and certain nutritional factors in the etiology or promotion of various malignant diseases has widely been studied. A link between dietary fat and cancer has long been proposed through various human epidemiologic and experimental data. High fat diets are associated with a high incidence and accelerated development of certain tumors, while there is evidence that dietary w-3 fatty acids have beneficial effects in cancer growth and metastasis. The relation between the different lipid formulations and cancer appears to be mainly related to the influence of specific fatty acids on the synthesis of the immunosuppressive prostaglandin E2. Omega-3 polyunsaturated fatty acids seem to have an anti-tumor effect through their immunomodulating, anti-inflammatory action and direct inhibition of tumor cell proliferation via alteration in prostaglandin E2 production.
C A Gogos; A Skoutelis; F Kalfarentzos
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The journal of nutrition, health & aging     Volume:  4     ISSN:  1279-7707     ISO Abbreviation:  J Nutr Health Aging     Publication Date:  2000  
Date Detail:
Created Date:  2000-11-15     Completed Date:  2001-03-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100893366     Medline TA:  J Nutr Health Aging     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  172-5     Citation Subset:  IM    
Patras University Medical School, Dpt of Medicine, Rion - Patras 26500, Patras, Greece.
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MeSH Terms
Dietary Fats / immunology,  pharmacology*,  therapeutic use
Disease Models, Animal
Fatty Acids / pharmacology
Fatty Acids, Omega-3 / immunology,  therapeutic use
Neoplasms / diet therapy,  epidemiology,  immunology*,  pathology
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Omega-3

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