Document Detail

The effects of lactic acid on PGE2 production by macrophages and human synovial fibroblasts: a possible explanation for problems associated with the degradation of poly(lactide) implants?
MedLine Citation:
PMID:  10172486     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to investigate the effects of lactic acid on cells found at the bone-implant interface in order to try to discover more about the effects of degradation of implants manufactured from poly(lactide). This study shows that human synovial fibroblasts and murine macrophages release prostaglandin E2 (PGE2) a bone resorbing and inflammatory mediator, into the surrounding medium when exposed to lactic acid. The production of PGE2 in response to lactate may help to explain isolated cases of inflammation and discomfort seen some time after fracture fixation with poly(lactide) implants.
E Dawes; N Rushton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical materials     Volume:  17     ISSN:  0267-6605     ISO Abbreviation:  Clin Mater     Publication Date:  1994  
Date Detail:
Created Date:  1996-01-29     Completed Date:  1996-01-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8707278     Medline TA:  Clin Mater     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  157-63     Citation Subset:  T    
University of Cambridge Orthopaedic Research Unit, Addenbrookes Hospital, UK.
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MeSH Terms
Dinoprostone / biosynthesis*
Fibroblasts / secretion
Lactates / pharmacokinetics*
Lactic Acid
Macrophages / secretion*
Prostheses and Implants*
Synovial Membrane / secretion*
Reg. No./Substance:
0/Lactates; 0/Polymers; 26100-51-6/poly(lactic acid); 363-24-6/Dinoprostone; 50-21-5/Lactic Acid

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