| The effects of kisspeptin-54 on blood pressure in humans and plasma kisspeptin concentrations in hypertensive diseases of pregnancy. | |
| | |
MedLine Citation:
|
PMID: 21039761 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: To investigate (i) if kisspeptin administration alters heart rate (HR) or blood pressure (BP) in healthy male and female volunteers, (ii) whether circulating plasma kisspeptin concentrations in healthy pregnant women and women with hypertensive diseases of pregnancy correlate with BP and (iii) whether women with hypertensive diseases of pregnancy have altered plasma kisspeptin concentrations. METHODS: We have previously reported the effects of administration of kisspeptin-54 on gonadotrophin secretion in healthy male and female volunteers. In these studies, cardiovascular parameters were not a primary endpoint. However, data were also collected on BP and HR for 4h post administration of kisspeptin-54. Blood samples were taken from 105 women in the third trimester of pregnancy (27 women with hypertensive diseases of pregnancy and 78 controls). Samples were assayed for plasma kisspeptin immunoreactivity (IR). RESULTS: Administration of kisspeptin was not associated with significant changes in HR or BP in healthy men or women. There was no significant correlation between plasma kisspeptin concentration and BP in healthy pregnant women or in those with hypertensive diseases of pregnancy. No significant differences in plasma kisspeptin-IR concentrations were observed between women with hypertensive diseases of pregnancy and normotensive pregnant controls, plasma kisspeptin concentrations ±SE: controls 2878 ± 157pmol l(-1) ; pregnancy-induced hypertension 2696 ± 299pmoll(-1) (95% CI vs. controls -514, 878pmoll(-1) ); pre-eclampsia 3519 ± 357 (95% CI vs. controls -1644, 362pmoll(-1) ). CONCLUSIONS: Elevation of plasma kisspeptin-IR is not associated with an alteration in BP in humans. |
| | |
Authors:
|
Gurjinder M K Nijher; Owais B Chaudhri; Radha Ramachandran; Kevin G Murphy; Sagen E K Zac-Varghese; Alexis Fowler; Krishna Chinthapalli; Michael Patterson; Emily L Thompson; Catherine Williamson; Sailesh Kumar; Mohammad A Ghatei; Stephen R Bloom; Waljit S Dhillo |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: British journal of clinical pharmacology Volume: 70 ISSN: 1365-2125 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-02 Completed Date: 2011-02-24 Revised Date: 2011-11-01 |
Medline Journal Info:
|
Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: England |
Other Details:
|
Languages: eng Pagination: 674-81 Citation Subset: IM |
Copyright Information:
|
© 2010 The Authors. British Journal of Clinical Pharmacology © 2010 The British Pharmacological Society. |
Affiliation:
|
Department of Investigative Medicine, Imperial College London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Pressure / drug effects*, physiology* Case-Control Studies Female Heart Rate / drug effects, physiology Humans Hypertension, Pregnancy-Induced / blood, physiopathology* Male Pre-Eclampsia / blood, physiopathology* Pregnancy Pregnancy Complications, Cardiovascular / blood, physiopathology* Pregnancy Trimester, Third Tumor Suppressor Proteins / blood*, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
|
//Biotechnology and Biological Sciences Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
|
0/KISS1 protein, human; 0/Tumor Suppressor Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Atenolol blunts blood pressure increase during dynamic resistance exercise in hypertensives.
Next Document: Nonlinear pharmacokinetics of piperacillin in healthy volunteers--implications for optimal dosage re...