Document Detail


The effects of kisspeptin-54 on blood pressure in humans and plasma kisspeptin concentrations in hypertensive diseases of pregnancy.
MedLine Citation:
PMID:  21039761     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: To investigate (i) if kisspeptin administration alters heart rate (HR) or blood pressure (BP) in healthy male and female volunteers, (ii) whether circulating plasma kisspeptin concentrations in healthy pregnant women and women with hypertensive diseases of pregnancy correlate with BP and (iii) whether women with hypertensive diseases of pregnancy have altered plasma kisspeptin concentrations.
METHODS: We have previously reported the effects of administration of kisspeptin-54 on gonadotrophin secretion in healthy male and female volunteers. In these studies, cardiovascular parameters were not a primary endpoint. However, data were also collected on BP and HR for 4h post administration of kisspeptin-54. Blood samples were taken from 105 women in the third trimester of pregnancy (27 women with hypertensive diseases of pregnancy and 78 controls). Samples were assayed for plasma kisspeptin immunoreactivity (IR).
RESULTS: Administration of kisspeptin was not associated with significant changes in HR or BP in healthy men or women. There was no significant correlation between plasma kisspeptin concentration and BP in healthy pregnant women or in those with hypertensive diseases of pregnancy. No significant differences in plasma kisspeptin-IR concentrations were observed between women with hypertensive diseases of pregnancy and normotensive pregnant controls, plasma kisspeptin concentrations ±SE: controls 2878 ± 157pmol l(-1) ; pregnancy-induced hypertension 2696 ± 299pmoll(-1) (95% CI vs. controls -514, 878pmoll(-1) ); pre-eclampsia 3519 ± 357 (95% CI vs. controls -1644, 362pmoll(-1) ).
CONCLUSIONS: Elevation of plasma kisspeptin-IR is not associated with an alteration in BP in humans.
Authors:
Gurjinder M K Nijher; Owais B Chaudhri; Radha Ramachandran; Kevin G Murphy; Sagen E K Zac-Varghese; Alexis Fowler; Krishna Chinthapalli; Michael Patterson; Emily L Thompson; Catherine Williamson; Sailesh Kumar; Mohammad A Ghatei; Stephen R Bloom; Waljit S Dhillo
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  70     ISSN:  1365-2125     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-02     Completed Date:  2011-02-24     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  674-81     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. British Journal of Clinical Pharmacology © 2010 The British Pharmacological Society.
Affiliation:
Department of Investigative Medicine, Imperial College London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects*,  physiology*
Case-Control Studies
Female
Heart Rate / drug effects,  physiology
Humans
Hypertension, Pregnancy-Induced / blood,  physiopathology*
Kisspeptins
Male
Pre-Eclampsia / blood,  physiopathology*
Pregnancy
Pregnancy Complications, Cardiovascular / blood,  physiopathology*
Pregnancy Trimester, Third
Tumor Suppressor Proteins / blood*,  pharmacology*
Grant Support
ID/Acronym/Agency:
//Biotechnology and Biological Sciences Research Council; //Wellcome Trust
Chemical
Reg. No./Substance:
0/KISS1 protein, human; 0/Kisspeptins; 0/Tumor Suppressor Proteins
Comments/Corrections

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