Document Detail


The effects of ketorolac and fentanyl on postoperative vomiting and analgesic requirements in children undergoing strabismus surgery.
MedLine Citation:
PMID:  7762839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifty-four ASA I and II children 1 to 10 yr of age undergoing strabismus surgery were randomized to receive in a double-blind fashion intravenous ketorolac (0.9 mg/kg), fentanyl (1 microgram/kg), or saline placebo (2 mL) during a standardized general anesthetic. Patients received no analgesic or antiemetics intraoperatively except for the study drug. Patients receiving ketorolac or placebo compared to fentanyl had a significantly lower incidence of postoperative vomiting in the day surgery unit (DSU) (P = 0.03) and overall (DSU plus home) (P = 0.005). The severity (number of episodes) of post-operative vomiting was significantly lower in the DSU, at home (first 24 h after hospital discharge), and overall for patients receiving ketorolac or placebo compared to fentanyl (P < 0.01). Postoperative pain scores and frequency of acetaminophen administration did not differ among the study groups, suggesting that the intraoperative use of ketorolac or fentanyl during pediatric strabismus surgery is unnecessary. No patients required fentanyl postoperatively, indicating that rectal acetaminophen administered in the postanesthesia recovery room provides sufficient analgesia for pediatric strabismus surgery. In conclusion, neither ketorolac nor fentanyl was associated with less postoperative vomiting or analgesic requirements compared to saline placebo administered during pediatric strabismus surgery. Fentanyl should be avoided, as it was associated with a significantly greater incidence of postoperative vomiting compared to ketorolac or placebo.
Authors:
H G Mendel; K M Guarnieri; L M Sundt; M C Torjman
Related Documents :
2715889 - Recovery from milk allergy in early childhood: antibody studies.
9081959 - Incidence of intermediate syndrome in organophosphorous poisoning.
15673859 - Optimal timing of acustimulation for antiemetic prophylaxis as an adjunct to ondansetro...
23953179 - One-year real-life efficacy of sitagliptin revealed importance of concomitant pioglitaz...
11249229 - Where there's hope.
21063309 - The efficacy of dexamethasone treatment in adult patients with acute bacterial meningitis.
19468739 - Long-term results of endonasal dacryocystorhinostomy.
18984969 - Postoperative adjuvant radiation therapy in the treatment of primary head and neck muco...
1932669 - Comparative effects of 5% ethanolamine oleate versus 5% sodium morrhuate for sclerother...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  80     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-06-27     Completed Date:  1995-06-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1129-33     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetaminophen / therapeutic use
Ambulatory Surgical Procedures
Analgesics, Non-Narcotic* / adverse effects
Anesthesia* / adverse effects
Child
Child, Preschool
Double-Blind Method
Fentanyl* / adverse effects
Humans
Infant
Ketorolac
Pain, Postoperative / drug therapy*
Postoperative Complications*
Strabismus / surgery*
Tolmetin / adverse effects,  analogs & derivatives*
Vomiting / chemically induced,  drug therapy,  etiology*
Chemical
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 103-90-2/Acetaminophen; 26171-23-3/Tolmetin; 437-38-7/Fentanyl; 66635-83-4/Ketorolac
Comments/Corrections
Comment In:
Anesth Analg. 1996 Apr;82(4):889-90   [PMID:  8615527 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Direct effects of halothane and isoflurane in infant rabbit hearts with right ventricular hypertroph...
Next Document:  Resuscitation from bupivacaine-induced asystole in rats: comparison of different cardioactive drugs.