Document Detail

The effects of an iron chelator on cellular injury induced by vascular stasis caused by hypothermia.
MedLine Citation:
PMID:  2172571     Owner:  NLM     Status:  MEDLINE    
Rewarming of a cooled rabbit leg was associated with the generation of oxygen-derived free radicals, shown to be instrumental for tissue injury occurring during rewarming. The present study used a compound that, by its ability to bind with free iron, can remove hydroxyl radical (OH.) from tissue. Deferoxamine reduced tissue injury during cooling and rewarming, as evidenced by its ability to decrease tissue release of lactic acid dehydrogenase and creatine kinase. Deferoxamine also reduced the formation of OH. and lipid peroxidation during the rewarming phase. This compound did not have any effect on the arterial blood flow pattern, which uniformly decreased during cooling and was restored during rewarming. The results of this study indicate the efficacy of deferoxamine in reducing cellular injury associated with cold and rewarming and further suggest a role for oxygen-derived free radicals in the pathophysiology of cold-rewarming injury.
J Iyengar; A George; J C Russell; D K Das
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  12     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-12-20     Completed Date:  1990-12-20     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  545-51     Citation Subset:  IM    
Department of Surgery, University of Connecticut School of Medicine, Farmington 06032-9984.
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MeSH Terms
Creatine Kinase / blood
Deferoxamine / pharmacology*
Hindlimb / blood supply
Hydroxides / metabolism
Hydroxyl Radical
Hypothermia, Induced*
Iron / metabolism*
L-Lactate Dehydrogenase / blood
Lipid Peroxides / metabolism
Malondialdehyde / blood
Muscles / metabolism,  pathology
Regional Blood Flow / drug effects
Reperfusion Injury / blood,  metabolism*,  pathology
Reg. No./Substance:
0/Hydroxides; 0/Lipid Peroxides; 3352-57-6/Hydroxyl Radical; 542-78-9/Malondialdehyde; 70-51-9/Deferoxamine; 7439-89-6/Iron; EC Dehydrogenase; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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