Document Detail


The effects of intravenous fentanyl and intravenous fentanyl combined with bupivacaine infiltration on the hemodynamic response to skull pin insertion.
MedLine Citation:
PMID:  15632536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was conducted to compare the effects of intravenous fentanyl and intravenous fentanyl combined with bupivacaine infiltration on the hemodynamic response to skull pin insertion. 120 ASA I-II patients scheduled for elective craniotomy were included. The fentanyl group (group F, n = 60) received fentanyl during induction and prior to skull pin insertion (2 and 1 microg . kg, respectively). The fentanyl-bupivacaine group (group FB, n = 60) received the same doses of fentanyl as well as scalp infiltration with 0.25% bupivacaine. The heart rate (HR) was not significantly different between the groups. HR, at 5 minutes after skull pin insertion in the group F and at 1 and 5 minutes after skull pin insertion in group FB, significantly decreased in comparison to the baseline values (P < 0.05). In both groups, HR at 1 and 5 minutes after skull pin insertion was significantly lower than HR just before skull pin insertion (P < 0.05). In group FB, the mean arterial pressure (MAP) at 1 and 5 minutes after skull pin insertion were significantly lower than that in group F (P < 0.05). In group F, MAP at 1 minute after skull pin insertion was higher than that of just before skull pin insertion (P < 0.05); however, MAP at 5 minutes after skull pin insertion was lower than that of just before skull pin insertion (P < 0.05). In group FB, MAP at 1 and 5 minutes after skull pin insertion was lower than that of just before skull pin insertion (P < 0.05). The hemodynamic response to skull pin insertion was effectively suppressed with both methods. Still, the addition of scalp infiltration to fentanyl did not provide any additional benefit. Administering an additional dose (1 microg . kg) of fentanyl just before skull pin insertion is recommended as a simple and effective option that requires no extra time.
Authors:
Karamehmet Yildiz; Halit Madenoglu; Kudret Dogru; Mustafa Sirri Kotanoglu; Aynur Akin; Adem Boyaci
Related Documents :
14051486 - Intravenous ether anesthesia.
3942666 - Effect of isoflurane on bronchomotor tone in man.
2415326 - A decrease in clonus amplitude by topical anesthesia.
9691866 - Comparison of the effects of sevoflurane, isoflurane and halothane on rat myocardium.
17106066 - Blunted lipolysis and fatty acid oxidation during moderate exercise in hiv-infected sub...
24787326 - Knee pain: safely strengthening your thigh muscles.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of neurosurgical anesthesiology     Volume:  17     ISSN:  0898-4921     ISO Abbreviation:  J Neurosurg Anesthesiol     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-05     Completed Date:  2005-03-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8910749     Medline TA:  J Neurosurg Anesthesiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9-12     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology, Erciyes University Gevher Nesibe Hospital, Kayseri, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Anesthesia, General*
Anesthetics, Intravenous*
Anesthetics, Local*
Blood Pressure / physiology
Bone Nails*
Bupivacaine*
Cross-Over Studies
Double-Blind Method
Female
Fentanyl*
Heart Rate / physiology
Hemodynamics / physiology*
Humans
Male
Middle Aged
Prospective Studies
Skull / surgery*
Chemical
Reg. No./Substance:
0/Anesthetics, Intravenous; 0/Anesthetics, Local; 2180-92-9/Bupivacaine; 437-38-7/Fentanyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The positive impact of hospice care on the surviving spouse.
Next Document:  Progressive suppression of motor evoked potentials during general anesthesia: the phenomenon of "ane...