Document Detail

The effects of intravenous clonidine on ventilation.
MedLine Citation:
PMID:  1909506     Owner:  NLM     Status:  MEDLINE    
The effects of clonidine, an alpha 2 adrenergic agonist, on ventilation were studied in a group of adult volunteers. The ventilatory variables measured were minute ventilation, respiratory rate, end-tidal carbon dioxide tension and the response to carbon dioxide challenge. We found no differences in minute ventilation, respiratory rate and end-tidal carbon dioxide tension, before and after clonidine administration. However, the ventilatory response to carbon dioxide was significantly attenuated following clonidine, suggesting that clonidine has respiratory depressant effects.
R Ooi; J Pattison; S A Feldman
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Anaesthesia     Volume:  46     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-10-08     Completed Date:  1991-10-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  632-3     Citation Subset:  AIM; IM    
Magill Department of Anaesthetics, Westminster Hospital, London.
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MeSH Terms
Blood Pressure / drug effects
Carbon Dioxide
Clonidine / administration & dosage,  pharmacology*
Depression, Chemical
Drug Evaluation
Heart Rate / drug effects
Injections, Intravenous
Respiration / drug effects*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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