Document Detail

The effects of intrauterine growth restriction and antenatal glucocorticoids on ovine fetal lung development.
MedLine Citation:
PMID:  22337223     Owner:  NLM     Status:  Publisher    
Intrauterine fetal growth restriction (IUGR) is associated with high rates of neonatal morbidity. IUGR babies are often born preterm and are therefore exposed to antenatal glucocorticoids. Antenatal glucocorticoids significantly improve overall survival rates of preterm infants, but there is a paucity of information about their effects on IUGR infants. We induced IUGR in sheep by single umbilical artery ligation (SUAL), or sham in control fetuses. To half the ewes, we administered betamethasone (BM) on days 5 (BM1) and 6 (BM2) following surgery and collected fetal lung tissue on day 7. SUAL alone was associated with higher circulating fetal cortisol levels (2.8±0.4 vs 1.0±0.4, P=0.001) compared to controls, but no changes in lung morphology or surfactant protein (SP) gene expression. BM was associated with a significant reduction in lung tissue density (P=0.048). There were no significant differences between groups in lung DNA concentration or septal crest density. SP-A, -B and -C gene expression was significantly increased in control and SUAL fetuses given BM. These results show that in SUAL fetuses, maternal betamethasone is associated with acceleration of fetal lung structure, as occurs in normally grown fetuses, and that betamethasone induces SP production, an effect not observed in SUAL-induced IUGR fetuses alone.
Amy E Sutherland; Kelly J Crossley; Beth J Allison; Graham Jenkin; Euan M Wallace; Suzanne L Miller
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-15
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1] The Ritchie Centre [A.E.S., K.J.C., B.J.A., G.J., E.M.W., S.L.M.], Monash Institute of Medical Research, Monash University, Clayton, Victoria, 3168, Australia [2] Department of Obstetrics & Gynaecology [A.E.S., G.J., E.M.W., S.L.M.], Monash Institute of Medical Research, Monash University, Clayton, Victoria, 3168, Australia.
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