Document Detail

The effects of intrathecal levobupivacaine and bupivacaine in the elderly.
MedLine Citation:
PMID:  19686477     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to compare the block durations and haemodynamic effects associated with intrathecal levobupivacaine or bupivacaine in elderly patients undergoing transurethral prostate surgery. Eighty patients were prospectively randomised to receive plain 1.5 ml levobupivacaine 0.5% (group levobupivacaine) or 1.5 ml plain bupivacaine 0.5% (group bupivacaine) in combination with fentanyl 0.3 ml (15 microg) for spinal anaesthesia. The time to reach T10 and peak sensory block level, and to maximum motor block were significantly shorter in group bupivacaine compared to group levobupivacaine (p < 0.05). Peak sensory block level was also significantly higher in group bupivacaine. In group bupivacaine, mean arterial pressure was significantly lower than group levobupivacaine, starting from 10 min until 30 min after injection (p < 0.05). Hypotension and nausea were less common in group levobupivacaine than group bupivacaine (p < 0.05). Because of the better haemodynamic stability and fewer side-effects associated with levobupivacaine, it may be preferred for spinal anaesthesia in elderly patients.
F Erdil; S Bulut; S Demirbilek; E Gedik; N Gulhas; M O Ersoy
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  64     ISSN:  1365-2044     ISO Abbreviation:  Anaesthesia     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-18     Completed Date:  2009-09-03     Revised Date:  2010-04-21    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  942-6     Citation Subset:  AIM; IM    
Department of Anaesthesiology and Reanimation, School of Medicine, Inonu University, Malatya, Turkey.
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MeSH Terms
Anesthesia, Spinal / adverse effects,  methods
Anesthetics, Local / adverse effects,  pharmacology*
Blood Pressure / drug effects
Bupivacaine / adverse effects,  analogs & derivatives,  pharmacology*
Fentanyl / pharmacology
Heart Rate / drug effects
Hypotension / chemically induced
Middle Aged
Movement / drug effects
Postoperative Nausea and Vomiting / chemically induced
Prospective Studies
Sensation / drug effects
Transurethral Resection of Prostate
Reg. No./Substance:
0/Anesthetics, Local; 0/levobupivacaine; 2180-92-9/Bupivacaine; 437-38-7/Fentanyl
Comment In:
Anaesthesia. 2010 Feb;65(2):212; author reply 212   [PMID:  20402855 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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