| The effects of intrathecal administration of arginine-vasopressin and substance P on blood pressure and adrenal secretion of epinephrine in rats. | |
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MedLine Citation:
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PMID: 2424966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of intrathecally administered arginine-vasopressin (AVP) and substance P (SP) on adrenal medullary secretion of epinephrine were examined in anesthetized Sprague-Dawley rats. Plasma epinephrine levels were measured in blood samples taken directly from the adrenal vein using a novel micropuncture technique. The blood samples (20-30 microliter in volume) were taken before, and 2 min, 15 min and 30 min after intrathecal injections of AVP, SP or vehicle only. Plasma was assayed for epinephrine using high pressure liquid chromatography. Adrenal venous epinephrine levels were not significantly altered by the intrathecal administration of AVP, thereby suggesting that adrenal epinephrine secretion is not involved in the cardiovascular responses previously reported to occur following similar doses of intrathecal AVP. Intrathecal SP administration, while causing blood pressure responses similar to those produced by AVP, resulted in significant increases in adrenal vein epinephrine. This finding suggests that activation of adrenal secretion of epinephrine may contribute to SP-initiated blood pressure changes. |
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Authors:
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C L Riphagen; L Bauce; W L Veale; Q J Pittman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the autonomic nervous system Volume: 16 ISSN: 0165-1838 ISO Abbreviation: J. Auton. Nerv. Syst. Publication Date: 1986 Jun |
Date Detail:
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Created Date: 1986-07-31 Completed Date: 1986-07-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8003419 Medline TA: J Auton Nerv Syst Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 91-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
/
blood supply,
drug effects,
secretion* Animals Arginine Vasopressin / administration & dosage, pharmacology* Blood Pressure / drug effects* Epinephrine / blood, secretion* Injections, Spinal Male Rats Rats, Inbred Strains Substance P / administration & dosage, pharmacology* Veins |
| Chemical | |
Reg. No./Substance:
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113-79-1/Arginine Vasopressin; 33507-63-0/Substance P; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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