Document Detail


The effects of intra-rectal and intra-peritoneal application of Origanum onites L. essential oil on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in the rat.
MedLine Citation:
PMID:  18222658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study is to investigate the treatment efficiency of intra-rectal (IR) and intra-peritoneal (IP) application of Origanum onites essential oil (OOEO), which is a well-known antioxidant, in the colitis model induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) and ethanol (E) in comparison with dexamethasone therapy through the morphologic damage score. Monoclonal antibodies against intercellular adhesion molecule-1 (ICAM-1, CD54), anti-rat granulocytes, and myeloperoxidase (MPO), were also investigated immunohistochemically. There was a significant difference in terms of ulceration, mucus cell depletion, inflammatory cell infiltration, vascular dilatation (p<0.001), crypt abscesses (p<0.01), and edema (p<0.05) between OOEO-1mg/kg-IR and control colitis groups. A significant difference was encountered in terms of mucus cell depletion, crypt abscesses, inflammatory cell infiltration, vascular dilatation (p<0.01), and ulceration (p<0.05) between the OOEO-0.1mg/kg-IR and control colitis groups. A significant difference was noticed in terms of ulceration, inflammatory cell infiltration, mucus cell depletion (p<0.001), vascular dilatation (p<0.01), and mucosal atrophy (p<0.05) between the OOEO-1mg/kg-IP and control colitis groups. There was a significant difference in terms of ulceration, mucus cell depletion, inflammatory cell infiltration (p<0.001), crypt abscesses, vascular dilatation (p<0.01), and mucosal atrophy (p<0.05) between the OOEO-0.1mg/kg-IP and control colitis groups. No significant difference was determined in terms of ulceration, inflammatory cyst, mucosal atrophy, edema, and vascular dilatation between the dexamethazone and control colitis groups (p>0.05). Under the present conditions, we concluded that IR and IP OOEO treatment, applied at the dosage of 0.1 or 1mg/kg/day, have a significant protective effect on the colonic injury.
Authors:
Emine Dundar; Esra Gurlek Olgun; Serap Isiksoy; Mine Kurkcuoglu; K Husnu Can Baser; Cengiz Bal
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Publication Detail:
Type:  Journal Article     Date:  2008-01-28
Journal Detail:
Title:  Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie     Volume:  59     ISSN:  0940-2993     ISO Abbreviation:  Exp. Toxicol. Pathol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-10     Completed Date:  2008-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208920     Medline TA:  Exp Toxicol Pathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  399-408     Citation Subset:  IM    
Affiliation:
Department of Pathology, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey. edundar_99@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Administration, Rectal
Animals
Antioxidants / administration & dosage,  isolation & purification,  therapeutic use*
Colitis / chemically induced,  drug therapy*,  pathology
Colitis, Ulcerative / chemically induced,  drug therapy,  pathology
Colon / drug effects*,  metabolism,  pathology
Dexamethasone / therapeutic use
Disease Models, Animal
Ethanol / toxicity
Gas Chromatography-Mass Spectrometry
Immunohistochemistry
Injections, Intraperitoneal
Intercellular Adhesion Molecule-1 / metabolism
Intestinal Mucosa / drug effects,  metabolism,  pathology
Oils, Volatile / administration & dosage,  isolation & purification,  therapeutic use*
Origanum / chemistry*
Peroxidase / metabolism
Rats
Rats, Sprague-Dawley
Trinitrobenzenesulfonic Acid / toxicity*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Oils, Volatile; 126547-89-5/Intercellular Adhesion Molecule-1; 2508-19-2/Trinitrobenzenesulfonic Acid; 50-02-2/Dexamethasone; 64-17-5/Ethanol; 8007-11-2/origanum oil; EC 1.11.1.7/Peroxidase

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