Document Detail


The effects of intra-articular methylprednisolone and exercise on the mechanical properties of articular cartilage in the horse.
MedLine Citation:
PMID:  9692065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Intra-articular corticosteroids are widely used as anti-inflammatory agents for symptomatic management of arthritis, but their administration with concurrent exercise remains controversial. Biochemical and morphologic analysis of treated cartilage has revealed conflicting results, but previous biomechanical assessment has not been undertaken. OBJECTIVE: To compare the biomechanical properties of intra-articular methylprednisolone acetate (MPA) and diluent treated cartilage in treadmill exercised horses. METHODS: Eight 2-year-old female horses had MPA or diluent administered into contralateral middle carpal joints at 14 day intervals for a total of four treatments per horse. Horses underwent a standard treadmill exercise protocol until euthanasia (day 70). Standard sites were tested on the third, radial and intermediate carpal bones using an automated indentation apparatus to obtain the creep and recovery behavior of the articular cartilage. Using previously validated biphasic creep indentation methodology, aggregate modulus, Poisson's ratio, permeability, shear modulus, thickness, creep and recovery equilibrium times and percent recovery were obtained at each site. Results were analyzed using ANOVA and multiple comparisons of the means (P < 0.05). RESULTS: Cartilage intrinsic material properties and thickness demonstrated significant differences between MPA and diluent treated joints. Diluent treated cartilage had a 97% increase in compressive stiffness modulus (P = 0.0001), was 121% more permeable (P = 0.0001), had 88% increase in shear modulus (P = 0.0001), and was 24% thicker (P = 0.0001) than MPA treated articular cartilage. CONCLUSIONS: The findings indicate that repetitive intra-articular administration of MPA to exercising horses alters the mechanical integrity of articular cartilage, which could lead to early cartilage degeneration.
Authors:
R C Murray; R M DeBowes; E M Gaughan; C F Zhu; K A Athanasiou
Related Documents :
1535635 - Lipocortins (annexins) 1, 2, 4 and 5 are increased in the central nervous system in mul...
15692465 - Microdermabrasion: a molecular analysis following a single treatment.
710995 - The determinants of flexor tendon fibrosis following trauma: an experimental study in r...
22890715 - Regulation of glucose kinetics during exercise by the glucagon-like peptide-1 receptor.
21242605 - Lower relative bone mineral content in obese adolescents: role of non-weight bearing ex...
8299605 - Lactate disposal in resting trained and untrained forearm skeletal muscle during high i...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society     Volume:  6     ISSN:  1063-4584     ISO Abbreviation:  Osteoarthr. Cartil.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-09-10     Completed Date:  1998-09-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9305697     Medline TA:  Osteoarthritis Cartilage     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  106-14     Citation Subset:  IM    
Affiliation:
Department of Clinical Veterinary Medicine, University of Cambridge, England, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Anti-Inflammatory Agents / administration & dosage,  adverse effects*
Biomechanics
Carpus, Animal*
Cartilage, Articular / drug effects*,  physiology
Female
Horses
Injections, Intra-Articular
Methylprednisolone / administration & dosage,  adverse effects,  analogs & derivatives*
Physical Conditioning, Animal / physiology*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 53-36-1/methylprednisolone acetate; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Acute synovitis and intra-articular methylprednisolone acetate in ponies.
Next Document:  Markers of cartilage and synovial metabolism in joint fluid and serum of patients with chondromalaci...