| The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women. | |
| | |
MedLine Citation:
|
PMID: 20921964 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Background:The problems of adherence to energy restriction in humans are well known.Objective:To compare the feasibility and effectiveness of intermittent continuous energy (IER) with continuous energy restriction (CER) for weight loss, insulin sensitivity and other metabolic disease risk markers.Design:Randomized comparison of a 25% energy restriction as IER (∼2710 kJ/day for 2 days/week) or CER (∼6276 kJ/day for 7 days/week) in 107 overweight or obese (mean (±s.d.) body mass index 30.6 (±5.1) kg m(-2)) premenopausal women observed over a period of 6 months. Weight, anthropometry, biomarkers for breast cancer, diabetes, cardiovascular disease and dementia risk; insulin resistance (HOMA), oxidative stress markers, leptin, adiponectin, insulin-like growth factor (IGF)-1 and IGF binding proteins 1 and 2, androgens, prolactin, inflammatory markers (high sensitivity C-reactive protein and sialic acid), lipids, blood pressure and brain-derived neurotrophic factor were assessed at baseline and after 1, 3 and 6 months.Results:Last observation carried forward analysis showed that IER and CER are equally effective for weight loss: mean (95% confidence interval ) weight change for IER was -6.4 (-7.9 to -4.8) kg vs -5.6 (-6.9 to -4.4) kg for CER (P-value for difference between groups=0.4). Both groups experienced comparable reductions in leptin, free androgen index, high-sensitivity C-reactive protein, total and LDL cholesterol, triglycerides, blood pressure and increases in sex hormone binding globulin, IGF binding proteins 1 and 2. Reductions in fasting insulin and insulin resistance were modest in both groups, but greater with IER than with CER; difference between groups for fasting insulin was -1.2 (-1.4 to -1.0) μU ml(-1) and for insulin resistance was -1.2 (-1.5 to -1.0) μU mmol(-1) l(-1) (both P=0.04).Conclusion:IER is as effective as CER with regard to weight loss, insulin sensitivity and other health biomarkers, and may be offered as an alternative equivalent to CER for weight loss and reducing disease risk. |
| | |
Authors:
|
M N Harvie; M Pegington; M P Mattson; J Frystyk; B Dillon; G Evans; J Cuzick; S A Jebb; B Martin; R G Cutler; T G Son; S Maudsley; O D Carlson; J M Egan; A Flyvbjerg; A Howell |
Related Documents
:
|
17508394 - Size and shape: the developmental regulation of static allometry in insects. 8923834 - Insulin-like growth factors enhance steroidogenic enzyme and corticotropin receptor mes... 16899554 - Endocrine signaling in caenorhabditis elegans controls stress response and longevity. 14709014 - Isolation and characterization of polyphenol type-a polymers from cinnamon with insulin... 10710454 - Salivary function and glycemic control in older persons with diabetes. 10079144 - Relationship between autofluorescence and advanced glycation end products in diabetic l... |
Publication Detail:
|
Type: Journal Article Date: 2010-10-05 |
Journal Detail:
|
Title: International journal of obesity (2005) Volume: 35 ISSN: 1476-5497 ISO Abbreviation: Int J Obes (Lond) Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-05-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101256108 Medline TA: Int J Obes (Lond) Country: England |
Other Details:
|
Languages: eng Pagination: 714-27 Citation Subset: IM |
Affiliation:
|
Genesis Prevention Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The relationship between body size and mortality in the linked Scottish Health Surveys: cross-sectio...
Next Document: Gender differences in the association between maternal smoking during pregnancy and childhood growth...