Document Detail


The effects of intense sound exposure on phase locking in the chick (Gallus domesticus) cochlear nerve.
MedLine Citation:
PMID:  17067297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Little is known about changes that occur to phase locking in the auditory nerve following exposure to intense and damaging levels of sound. The present study evaluated synchronization in the discharge patterns of cochlear nerve units collected from two groups of young chicks (Gallus domesticus), one shortly after removal from an exposure to a 120-dB, 900-Hz pure tone for 48 h and the other from a group of non-exposed control animals. Spontaneous activity, the characteristic frequency (CF), CF threshold and a phase-locked peri-stimulus time histogram were obtained for every unit in each group. Vector strength and temporal dispersion were calculated from these peri-stimulus time histograms, and plotted against the unit's CF. All parameters of unit responses were then compared between control and exposed units. The results in exposed units revealed that CF thresholds were elevated by 30-35 dB whereas spontaneous activity declined by 24%. In both control and exposed units a high degree of synchronization was observed in the low frequencies. The level of synchronization above approximately 0.5 kHz then systematically declined. The vector strengths in units recorded shortly after removal from the exposure were identical to those seen in control chicks. The deterioration in discharge activity of exposed units, seen in CF threshold and spontaneous activity, contrasted with the total absence of any overstimulation effect on synchronization. This suggested that synchronization arises from mechanisms unscathed by the acoustic trauma induced by the exposure.
Authors:
Adam C Furman; Michael Avissar; James C Saunders
Related Documents :
3964247 - Motor unit potentials at high muscle activity recorded by selective electrodes.
23155007 - Effect of combinations of monochromatic lights on growth and productive performance of ...
23767997 - Socially adjusted synchrony in the activity profiles of common marmosets in light-dark ...
25435617 - Ga3-mediated dormancy alleviation in the reputed african potato, hypoxis hemerocallidea.
24223567 - Kinematic and neurophysiological consequences of an assisted-force-feedback brain-machi...
19754267 - Biophoton detection and low-intensity light therapy: a potential clinical partnership.
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  24     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-27     Completed Date:  2006-12-21     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  2003-10     Citation Subset:  IM    
Affiliation:
Auditory Research Laboratory, Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, 5-Ravdin-ORL, 3400 Spruce Street, Philadelphia, PA 19104, USA. acfurman@mail.med.upenn.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation / methods
Animals
Animals, Newborn
Auditory Pathways / physiology
Auditory Threshold / physiology,  radiation effects
Chickens / physiology*
Cochlear Nerve / physiology*
Dose-Response Relationship, Radiation
Evoked Potentials, Auditory / physiology*,  radiation effects
Sound*
Grant Support
ID/Acronym/Agency:
DC 000710/DC/NIDCD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  5-HT1B receptor-mediated presynaptic inhibition at the calyx of Held of immature rats.
Next Document:  PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male ra...