Document Detail


The effects on increasing cardiac output with adrenaline or isoprenaline on arterial haemoglobin oxygen saturation and shunt during one-lung ventilation.
MedLine Citation:
PMID:  11153288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Theoretically, if the cardiac output were increased in the presence of a given intrapulmonary shunt, the arterial haemoglobin oxygen saturation (SaO2) should improve as the venous oxygen extraction per ml of blood decreases. To test this hypothesis, eight pigs were subjected to one-lung ventilation and adrenaline and isoprenaline infusions used to increase the cardiac output. The mixed venous oxygen, shunt fraction and oxygen consumption were measured. With both adrenaline and isoprenaline, although there was a small rise in mixed venous oxygen content, there was a fall in SaO2. With adrenaline, the mean shunt rose from 48% to 65%, the mean oxygen consumption rose from 126 ml/min to 134 ml/min and the mean SaO2 fell from 86.9% to 82.5%. With isoprenaline, the mean shunt rose from 45% to 59%, the mean oxygen consumption rose from 121 ml/min to 137 ml/min and the mean SaO2 fell from 89.5% to 84.7%. It is concluded that potential improvement in SaO2, which might occur from a catecholamine-induced increase in mixed venous oxygen content during one-lung ventilation, is more than offset by increased shunting and oxygen consumption which reduce SaO2.
Authors:
W J Russell; M F James
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  28     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-10     Completed Date:  2001-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  636-41     Citation Subset:  IM    
Affiliation:
Department of Anaesthesia, University of Cape Town, South Africa.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists / pharmacology*
Animals
Cardiac Output / drug effects*
Epinephrine / pharmacology*
Hemoglobins / metabolism*
Isoproterenol / pharmacology*
Oxygen / blood*
Oxygen Consumption / drug effects,  physiology
Respiration, Artificial*
Swine
Vasoconstrictor Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Hemoglobins; 0/Vasoconstrictor Agents; 51-43-4/Epinephrine; 7683-59-2/Isoproterenol; 7782-44-7/Oxygen
Comments/Corrections
Comment In:
Anaesth Intensive Care. 2001 Aug;29(4):435-6   [PMID:  11512658 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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