| The effects of increased endurance training load on biomarkers of heat intolerance during intense exercise in the heat. | |
| | |
MedLine Citation:
|
PMID: 19767796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of increased training (IT) load on plasma concentrations of lipopolysaccharides (LPS), proinflammatory cytokines, and anti-LPS antibodies during exercise in the heat were investigated in 18 male runners, who performed 14 days of normal training (NT) or 14 days of 20% IT load in 2 equal groups. Before (trial 1) and after (trial 2) the training intervention, all subjects ran at 70% maximum oxygen uptake on a treadmill under hot (35 degrees C) and humid (~40%) conditions, until core temperature reached 39.5 degrees C or volitional exhaustion. Venous blood samples were drawn before, after, and 1.5 h after exercise. Plasma LPS concentration after exercise increased by 71% (trial 1, p < 0.05) and 21% (trial 2) in the NT group and by 92% (trial 1, p < 0.01) and 199% (trial 2, p < 0.01) in the IT group. Postintervention plasma LPS concentration was 35% lower before exercise (p < 0.05) and 47% lower during recovery (p < 0.01) in the IT than in the NT group. Anti-LPS IgM concentration during recovery was 35% lower in the IT than in the NT group (p < 0.05). Plasma interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha concentration after exercise (IL-6, 3-7 times, p < 0.01, and TNF-alpha, 33%, p < 0.01) and during recovery (IL-6, 2-4 times, p < 0.05, and TNF-alpha, 30%, p < 0.01) were higher than at rest within each group. These data suggest that a short-term tolerable increase in training load may protect against developing endotoxemia during exercise in the heat. |
| | |
Authors:
|
Chin Leong Lim; David Pyne; Peggy Horn; Amelia Kalz; Philo Saunders; Jonathan Peake; Katsuhiko Suzuki; Gary Wilson; Laurel T Mackinnon |
Related Documents
:
|
6601686 - Physical and biochemical energy balance during an isometric tetanus and steady state re... 1503496 - Thermal and sweating responses in normal and atopic subjects under internal and moderat... 11691886 - Muscle heat production and anaerobic energy turnover during repeated intense dynamic ex... 15595286 - Responses of children with cerebral palsy to treadmill walking exercise in the heat. 15570136 - Intermittent exercise test in chronic obstructive pulmonary disease patients: how do th... 6601686 - Physical and biochemical energy balance during an isometric tetanus and steady state re... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme Volume: 34 ISSN: 1715-5312 ISO Abbreviation: - Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-09-21 Completed Date: 2009-10-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101264333 Medline TA: Appl Physiol Nutr Metab Country: Canada |
Other Details:
|
Languages: eng Pagination: 616-24 Citation Subset: IM |
Affiliation:
|
School of Human Movement Studies, University of Queensland, St Lucia, 4072, Brisbane, Australia. limcl@dso.org.sg |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antibodies, Bacterial
/
blood* Biological Markers / blood Cytokines / blood* Endotoxemia / blood, etiology, prevention & control* Heart Rate Heat Stress Disorders / blood, etiology, prevention & control* Hot Temperature / adverse effects* Humans Humidity Inflammation Mediators / blood* Interleukin-6 / blood Lipopolysaccharides / blood*, immunology Male Oxygen Consumption Physical Endurance* Sweating Time Factors Tumor Necrosis Factor-alpha / blood |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Bacterial; 0/Biological Markers; 0/Cytokines; 0/IL6 protein, human; 0/Inflammation Mediators; 0/Interleukin-6; 0/Lipopolysaccharides; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Child-adult differences in muscle strength and activation pattern during isometric elbow flexion and...
Next Document: Effects of the self-contained breathing apparatus on left-ventricular function at rest and during gr...