Document Detail


The effects of inadvertent exposure of mefloquine chemoprophylaxis on pregnancy outcomes and infants of US Army servicewomen.
MedLine Citation:
PMID:  9291347     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During US military operations in Somalia, mefloquine, a drug for malaria chemoprophylaxis, was not approved for use in pregnant women. Some female soldiers inadvertently used mefloquine before becoming aware of their pregnancy. A registry was established to follow the outcomes of these pregnancies. Questionnaires were administered at the time the pregnancy was diagnosed, after termination or delivery, and at 1 year after birth. Seventy-two soldiers were eligible for the registry. There were 17 elective abortions, 12 spontaneous abortions, 1 molar pregnancy, and 23 live births. The outcome for 19 soldiers was unknown. An unexpected high rate of spontaneous abortions was observed. All infants were healthy at birth, with no major congenital malformations. One infant died at 4 months of viral pneumonitis. At 1 year of age, 13 infants were reported to be healthy, with normal cognitive and motor development. This study provides additional postmarketing data that mefloquine does not cause gross congenital malformations.
Authors:
B L Smoak; J V Writer; L W Keep; J Cowan; J L Chantelois
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  176     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-03     Completed Date:  1997-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  831-3     Citation Subset:  AIM; IM    
Affiliation:
Division of Preventive Medicine, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antimalarials / adverse effects*
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Mefloquine / adverse effects*
Military Personnel*
Pregnancy
Pregnancy Outcome*
Registries
United States
Chemical
Reg. No./Substance:
0/Antimalarials; 53230-10-7/Mefloquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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