| The effects of inadvertent exposure of mefloquine chemoprophylaxis on pregnancy outcomes and infants of US Army servicewomen. | |
| | |
MedLine Citation:
|
PMID: 9291347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
During US military operations in Somalia, mefloquine, a drug for malaria chemoprophylaxis, was not approved for use in pregnant women. Some female soldiers inadvertently used mefloquine before becoming aware of their pregnancy. A registry was established to follow the outcomes of these pregnancies. Questionnaires were administered at the time the pregnancy was diagnosed, after termination or delivery, and at 1 year after birth. Seventy-two soldiers were eligible for the registry. There were 17 elective abortions, 12 spontaneous abortions, 1 molar pregnancy, and 23 live births. The outcome for 19 soldiers was unknown. An unexpected high rate of spontaneous abortions was observed. All infants were healthy at birth, with no major congenital malformations. One infant died at 4 months of viral pneumonitis. At 1 year of age, 13 infants were reported to be healthy, with normal cognitive and motor development. This study provides additional postmarketing data that mefloquine does not cause gross congenital malformations. |
| | |
Authors:
|
B L Smoak; J V Writer; L W Keep; J Cowan; J L Chantelois |
Related Documents
:
|
12186167 - Incidence of neural tube defects in ontario, 1986-1999. 8433417 - Osmol gaps revisited: normal values and limitations. 6874207 - Drinking habits and death. the yugoslavia cardiovascular disease study. 15541407 - Comparing vaginal and buccal misoprostol when used after methotrexate for early abortion. 20666087 - Newborn hearing screening: a regional example for national care. 3177347 - Deaths in custody. atlanta city jail and fulton county jail, 1974-1985. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: The Journal of infectious diseases Volume: 176 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1997 Sep |
Date Detail:
|
Created Date: 1997-10-03 Completed Date: 1997-10-03 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 831-3 Citation Subset: AIM; IM |
Affiliation:
|
Division of Preventive Medicine, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antimalarials / adverse effects* Female Follow-Up Studies Humans Infant Infant, Newborn Mefloquine / adverse effects* Military Personnel* Pregnancy Pregnancy Outcome* Registries United States |
| Chemical | |
Reg. No./Substance:
|
0/Antimalarials; 53230-10-7/Mefloquine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association of recurrent vaginal candidiasis and secretory ABO and Lewis phenotype.
Next Document: Cryptosporidiosis-induced impairment of ion transport and Na+-glucose absorption in adult immunocomp...