| The effects in myometrial preparations of D2343, a beta 2-adrenoceptor agonist possessing alpha 1-receptor blocking qualities. | |
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MedLine Citation:
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PMID: 6152105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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D2343 is a compound with about the same beta 2-adrenoceptor-agonist effect as terbutaline and exhibiting in addition an alpha 1-receptor inhibitory activity. D2343 has been compared to the beta 2-agonist terbutaline on oestrogenized uterine preparations from rat and rabbit (in vitro and in vivo) and in myometrial strips from homo. Generally, D2343 has shown an ability to relax the uterine muscles to the same degree as terbutaline or even more, especially when the two drugs were compared in vitro in preparations from rabbit and rat. |
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Authors:
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O A Olsson; B Ahlquist; B Gustafsson; G Persson |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Acta pharmacologica et toxicologica Volume: 55 ISSN: 0001-6683 ISO Abbreviation: Acta Pharmacol Toxicol (Copenh) Publication Date: 1984 Nov |
Date Detail:
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Created Date: 1985-04-15 Completed Date: 1985-04-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370572 Medline TA: Acta Pharmacol Toxicol (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 391-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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pharmacology* Adrenergic beta-Agonists / pharmacology* Animals Carbachol / antagonists & inhibitors Estradiol / pharmacology Female Humans Octopamine / analogs & derivatives*, pharmacology Oxytocin / antagonists & inhibitors Rabbits Rats Rats, Inbred Strains Terbutaline / pharmacology Uterine Contraction / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Agonists; 104-14-3/Octopamine; 23031-25-6/Terbutaline; 50-28-2/Estradiol; 50-56-6/Oxytocin; 51-83-2/Carbachol; 72734-63-5/D 2343 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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