Document Detail


The effects of impact and non-impact exercise on circulating markers of collagen remodelling in humans.
MedLine Citation:
PMID:  16815778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exercise has been shown to influence collagen synthesis and degradation. The aim of this study was to determine whether the stimulus for these changes is metabolic or mechanical. Eight healthy adults aged 22 +/- 4 years (mean +/- s) completed two exercise bouts-a 10 km road run and a deep water running session. Blood samples were collected before exercise and on days 1, 2, 3, 6 and 10 after exercise for measurement of creatine kinase activity, type IV collagen antigenicity, and concentrations of matrix metalloproteinase (MMP)- 9, tissue inhibitors of metalloproteinase (TIMP)- 1 and -2, and the MMP-2/TIMP-2 complex. Serum creatine kinase was elevated 24 h after the road run, but unchanged after the deep water running session. Serum collagen IV antigenicity decreased after both the road run and the deep water running session, suggesting suppressed type IV collagen synthesis in response to exercise, although serum MMPs and TIMPs remained unchanged after exercise. These results suggest that collagen IV synthesis is temporarily suppressed after exercise, irrespective of exercise type.
Authors:
Abigail L Mackey; Alan E Donnelly; Alan Swanton; Fiona Murray; Taina Turpeenniemi-Hujanen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of sports sciences     Volume:  24     ISSN:  0264-0414     ISO Abbreviation:  J Sports Sci     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405364     Medline TA:  J Sports Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  843-8     Citation Subset:  IM    
Affiliation:
Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Collagen Type IV / immunology*
Creatine Kinase / blood
Epitopes / blood
Female
Humans
Immersion
Male
Matrix Metalloproteinase 2 / blood*
Matrix Metalloproteinase 9 / blood*
Running / physiology*
Tissue Inhibitor of Metalloproteinase-1 / blood*
Tissue Inhibitor of Metalloproteinase-2 / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Collagen Type IV; 0/Epitopes; 0/Tissue Inhibitor of Metalloproteinase-1; 127497-59-0/Tissue Inhibitor of Metalloproteinase-2; EC 2.7.3.2/Creatine Kinase; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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