| The effects of impact and non-impact exercise on circulating markers of collagen remodelling in humans. | |
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MedLine Citation:
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PMID: 16815778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise has been shown to influence collagen synthesis and degradation. The aim of this study was to determine whether the stimulus for these changes is metabolic or mechanical. Eight healthy adults aged 22 +/- 4 years (mean +/- s) completed two exercise bouts-a 10 km road run and a deep water running session. Blood samples were collected before exercise and on days 1, 2, 3, 6 and 10 after exercise for measurement of creatine kinase activity, type IV collagen antigenicity, and concentrations of matrix metalloproteinase (MMP)- 9, tissue inhibitors of metalloproteinase (TIMP)- 1 and -2, and the MMP-2/TIMP-2 complex. Serum creatine kinase was elevated 24 h after the road run, but unchanged after the deep water running session. Serum collagen IV antigenicity decreased after both the road run and the deep water running session, suggesting suppressed type IV collagen synthesis in response to exercise, although serum MMPs and TIMPs remained unchanged after exercise. These results suggest that collagen IV synthesis is temporarily suppressed after exercise, irrespective of exercise type. |
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Authors:
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Abigail L Mackey; Alan E Donnelly; Alan Swanton; Fiona Murray; Taina Turpeenniemi-Hujanen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of sports sciences Volume: 24 ISSN: 0264-0414 ISO Abbreviation: J Sports Sci Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-07-03 Completed Date: 2006-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8405364 Medline TA: J Sports Sci Country: England |
Other Details:
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Languages: eng Pagination: 843-8 Citation Subset: IM |
Affiliation:
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Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Collagen Type IV / immunology* Creatine Kinase / blood Epitopes / blood Female Humans Immersion Male Matrix Metalloproteinase 2 / blood* Matrix Metalloproteinase 9 / blood* Running / physiology* Tissue Inhibitor of Metalloproteinase-1 / blood* Tissue Inhibitor of Metalloproteinase-2 / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Collagen Type IV; 0/Epitopes; 0/Tissue Inhibitor of Metalloproteinase-1; 127497-59-0/Tissue Inhibitor of Metalloproteinase-2; EC 2.7.3.2/Creatine Kinase; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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