| The effects of hypertension on the paediatric brain: a justifiable concern. | |
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MedLine Citation:
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PMID: 20675195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prevalence of hypertension in children is increasing but its neurological effects are under-recognised. Here, we describe acute and chronic effects of childhood hypertension on the nervous system. Acute neurological involvement ranges from posterior reversible encephalopathy syndrome to, possibly, infarction and haemorrhage. Children with chronic hypertension are likely to have learning disabilities and deficiencies in executive function, which are potentially reversible with antihypertensive treatment. These cognitive defects may be secondary to abnormal regulation of cerebral blood flow. Raised blood pressure in childhood could also contribute to the early development of atherosclerosis, which can have both short-term and long-term adverse effects on vasculature. Clinical studies are needed to better define the full clinical range of paediatric hypertension on a child's nervous system. Furthermore, accurate biomarkers to define cognitive abnormalities and cerebral involvement need to be identified. |
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Authors:
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Madhu Sharma; Juan C Kupferman; Yuri Brosgol; Kara Paterno; Sharon Goodman; Isak Prohovnik; Fenella J Kirkham; Steven G Pavlakis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-30 |
Journal Detail:
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Title: Lancet neurology Volume: 9 ISSN: 1474-4465 ISO Abbreviation: Lancet Neurol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-20 Completed Date: 2010-09-13 Revised Date: 2010-10-28 |
Medline Journal Info:
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Nlm Unique ID: 101139309 Medline TA: Lancet Neurol Country: England |
Other Details:
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Languages: eng Pagination: 933-40 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pediatrics, Maimonides Infants and Childrens' Hospital, New York, NY, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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pathology* Cerebrovascular Disorders / complications Child Cognition Disorders / etiology, pathology Humans Hypertension / etiology, pathology* Magnetic Resonance Imaging Pediatrics* |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Comments/Corrections | |
Comment In:
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Lancet Neurol. 2010 Nov;9(11):1046-7; author reply 1047
[PMID:
20965431
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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