Document Detail

On the effects of human galanin in man.
MedLine Citation:
PMID:  7689499     Owner:  NLM     Status:  MEDLINE    
Human galanin was recently isolated and sequenced and was found to differ from porcine galanin, hitherto used for studies in humans, in several important respects. We therefore synthesized and purified human galanin and infused it i.v. at a rate of 74 into six healthy volunteers for 60 min during a hyperglycaemic clamp. The clamp was achieved by i.v. infusion of glucose at a rate which in a control experiment had been demonstrated to maintain the plasma glucose level at 12-13 mmol/l for 90 min. Galanin concentrations reached a plateau of approximately 1500 pmol/l throughout the infusion as opposed to pre-infusion and control levels of 20-30 pmol/l. The glucose levels obtained in the two experiments were indistinguishable. Plasma levels of C-peptide and insulin increased significantly in both experiments and the dynamic concentration curves were almost identical. Glucagon concentrations in plasma decreased significantly and similarly. Growth hormone levels, however, increased eight-fold during galanin infusions. Galanin was eliminated from plasma with a half-life of 3.7 +/- 0.4 min, similar to that of porcine galanin. It is concluded that human galanin powerfully stimulates growth hormone secretion in man, but has no effect on pancreatic endocrine secretion or glucose metabolism in the concentrations obtained in this study.
J J Holst; M Bersani; A Hvidberg; U Knigge; E Christiansen; S Madsbad; H Harling; H Kofod
Related Documents :
7362859 - Prematurity in the rat. ii. effect of hypothermia.
7028479 - Hormonal changes associated with long distance exercise.
3063839 - Alterations in lipid and carbohydrate metabolism in sepsis.
218419 - Effect of propranolol on the plasma cyclic amp and cyclic gmp levels to massive doses o...
6255719 - Cyclic amp and metabolic substrates following hemorrhage in awake and anesthetized rats.
34629 - Dopamine during alpha- or beta-adrenergic blockade in man. hormonal, metabolic, and car...
1262439 - The menopausal transition: analysis of lh, fsh, estradiol, and progesterone concentrati...
8275329 - Determination of the structural requirements for the inhibitory action of gastrin-relea...
3957129 - Determination of lamellar body phospholipids in amniotic fluid: a method to predict whe...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetologia     Volume:  36     ISSN:  0012-186X     ISO Abbreviation:  Diabetologia     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-09-24     Completed Date:  1993-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  653-7     Citation Subset:  IM    
Department of Medical Physiology, Panum Institute, University of Copenhagen, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Glucose / metabolism*
C-Peptide / blood*
Glucose Clamp Technique
Growth Hormone / blood
Infusions, Intravenous
Insulin / blood*
Middle Aged
Neuropeptides / pharmacology*
Peptides / administration & dosage,  blood,  pharmacology*
Reg. No./Substance:
0/Blood Glucose; 0/C-Peptide; 0/Neuropeptides; 0/Peptides; 11061-68-0/Insulin; 88813-36-9/Galanin; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Natural killer cell depletion and diabetes mellitus in the BB/Wor rat (revisited).
Next Document:  Differential localization by in situ hybridization of distinct keratin mRNA species during intestina...