| The effects of high shear blending on alpha-lactose monohydrate. | |
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MedLine Citation:
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PMID: 17398047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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alpha-Lactose monohydrate is an important pharmaceutical excipient used extensively in dry powder inhaler (DPI) formulations. The ways in which a high shear blending process affect this material have been investigated and important process parameters have been identified. Total energy input (kJ/kg), blade design and the conditions in which lactose was stored prior to blending were found to have the most significant effect on the apparent particle size distribution of the processed material, which may subsequently affect the performance of DPI formulations. The power conditions used during blending, equipment temperature and humidity of the headspace above the powder were found to be less important in this respect. Additionally, it was found that high energy blending could induce changes in the water sorption characteristics of the material, although the formation of amorphous material could not be confirmed. |
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Authors:
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R H Bridson; P T Robbins; Y Chen; D Westerman; C R Gillham; T C Roche; J P K Seville |
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Publication Detail:
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Type: Journal Article Date: 2007-02-23 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 339 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-02 Completed Date: 2007-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 84-90 Citation Subset: IM |
Affiliation:
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Centre for Formulation Engineering, Department of Chemical Engineering, University of Birmingham, Birmingham B15 2TT, United Kingdom. r.h.bridson@bham.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Excipients
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chemistry* Humidity Lactose / chemistry* Nebulizers and Vaporizers Particle Size Surface Properties Technology, Pharmaceutical* Temperature |
| Chemical | |
Reg. No./Substance:
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0/Excipients; 63-42-3/Lactose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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