Document Detail

The effects of high shear blending on alpha-lactose monohydrate.
MedLine Citation:
PMID:  17398047     Owner:  NLM     Status:  MEDLINE    
alpha-Lactose monohydrate is an important pharmaceutical excipient used extensively in dry powder inhaler (DPI) formulations. The ways in which a high shear blending process affect this material have been investigated and important process parameters have been identified. Total energy input (kJ/kg), blade design and the conditions in which lactose was stored prior to blending were found to have the most significant effect on the apparent particle size distribution of the processed material, which may subsequently affect the performance of DPI formulations. The power conditions used during blending, equipment temperature and humidity of the headspace above the powder were found to be less important in this respect. Additionally, it was found that high energy blending could induce changes in the water sorption characteristics of the material, although the formation of amorphous material could not be confirmed.
R H Bridson; P T Robbins; Y Chen; D Westerman; C R Gillham; T C Roche; J P K Seville
Related Documents :
17766507 - Perceived milk intolerance is related to bone mineral content in 10- to 13-year-old fem...
10416157 - Evaluation of cheddar cheese as a food carrier for delivery of a probiotic strain to th...
17640417 - Contents of conjugated linoleic acid isomers in ruminant-derived foods and estimation o...
24254357 - The phytate and mineral content of some cereals, cereal products, legumes, legume produ...
21968287 - Efficiency of host utilisation by coleopteran parasitoid.
23832157 - Frames, claims and audiences: construction of food allergies in the canadian media.
Publication Detail:
Type:  Journal Article     Date:  2007-02-23
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  339     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-02     Completed Date:  2007-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  84-90     Citation Subset:  IM    
Centre for Formulation Engineering, Department of Chemical Engineering, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Excipients / chemistry*
Lactose / chemistry*
Nebulizers and Vaporizers
Particle Size
Surface Properties
Technology, Pharmaceutical*
Reg. No./Substance:
0/Excipients; 63-42-3/Lactose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Immobilization and bioactivity of glucose oxidase in hydrogel microspheres formulated by an emulsifi...
Next Document:  Development of carbonyl iron/ethylcellulose core/shell nanoparticles for biomedical applications.