Document Detail


The effects of high molecular weight hydroxyethyl starch solutions on platelets.
MedLine Citation:
PMID:  15333389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Physicochemical characteristics of hydroxyethyl starch (HES) molecules determine their side effects on hemostasis. Our aim in the present experiments was to test the antiplatelet effect of novel high molecular weight HES. Citrated whole blood was hemodiluted in vitro (0% and 20%) with either HES 550 (Hextend), HES 600 (6%Hetastarch-Baxter), HES 200 (Elohäst), or the solvent of Hextend in its commercially available solution. The availability of glycoprotein IIb-IIIa was assessed on nonstimulated and on agonist-induced platelets using flow cytometry. Glycoprotein IIb-IIIa availability increased significantly after hemodilution with Hextend and its solvent by 23% and 24%, respectively, but decreased in the presence of 6% Hetastarch-Baxter and Elohäst by 18% and 15%, respectively, with no significant difference between the latter two colloids. This study shows that Hextend does not inhibit platelet function as anticipated by its high molecular weight and degree of substitution. The unexpected platelet stimulating effect of Hextend is unique among the currently available HES preparations and may, at least in part, be induced by its solvent containing calcium chloride dihydrate (2.5 mmol/L). The platelet-inhibiting effect of 6%Hetastarch-Baxter was not significantly different from that of medium molecular weight HES 200.
Authors:
Engelbert Deusch; Ulrich Thaler; Sibylle A Kozek-Langenecker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  99     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-30     Completed Date:  2004-09-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  665-8, table of contents     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology and Intensive Care (B), Vienna Medical University, Waehringer Guertel 18-20, 1090-Vienna, Austria. engelbert.deusch@meduni.ac.at
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Platelets / drug effects*,  physiology
Dual Specificity Phosphatase 2
Flow Cytometry
Hemodilution
Hetastarch / pharmacology*
Humans
Male
Molecular Weight
Peptide Fragments / pharmacology
Platelet Aggregation Inhibitors / pharmacology
Platelet Glycoprotein GPIIb-IIIa Complex / metabolism
Protein Phosphatase 2
Protein Tyrosine Phosphatases / metabolism
Solutions
Chemical
Reg. No./Substance:
0/Peptide Fragments; 0/Platelet Aggregation Inhibitors; 0/Platelet Glycoprotein GPIIb-IIIa Complex; 0/Solutions; 0/thrombin receptor peptide (42-47); 9005-27-0/Hetastarch; EC 3.1.3.16/Protein Phosphatase 2; EC 3.1.3.48/DUSP2 protein, human; EC 3.1.3.48/Dual Specificity Phosphatase 2; EC 3.1.3.48/Protein Tyrosine Phosphatases
Comments/Corrections
Comment In:
Anesth Analg. 2005 May;100(5):1538; author reply 1538-9   [PMID:  15845726 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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