Document Detail


The effects of high-carbohydrate and high-fat diets on the serum lipid and lipoprotein concentrations of endurance athletes.
MedLine Citation:
PMID:  6436637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the effects of high-carbohydrate and high-fat diets on the serum lipid levels of distance runners. For seven days before each study, subjects consumed a diet containing 15% protein, 32% fat, and 53% carbohydrate. During 14-day experimental periods, a control group (n = 10) continued the same diet while two other groups consumed 69% of their calories as either carbohydrate (n = 13) or fat (n = 14). High-density lipoprotein (HDL)-cholesterol decreased 9% during the high-carbohydrate diet because of a 26% fall in the HDL2 fraction (1.063 to 1.125 g/mL). These changes were not accompanied by changes in the levels of apolipoproteins (apo) A-I or A-II. Total and low-density lipoprotein (LDL)-cholesterol initially decreased but subsequently exceeded pre-diet values while triglyceride concentrations increased 30% to 50%. Postheparin lipoprotein lipase activity (LPLA) fell 20%. Despite these dietary effects, HDL and HDL2 cholesterol concentrations in the athletes remained above values typical of sedentary men. The high-fat diet produced different effects on the serum lipids and lipoprotein levels of the athletes. HDL levels changed little during the study although HDL-cholesterol and apo A-I on the last diet day were both slightly above initial values. The high-fat diet provided 111 g of saturated fat per day but had surprisingly little effect on total and LDL-cholesterol whereas serum triglycerides fell by 10% to 20%. Postheparin LPLA increased 30% with fat feeding and the changes in LPLA correlated with alterations in triglyceride levels (r = -0.53, P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
P D Thompson; E M Cullinane; R Eshleman; M A Kantor; P N Herbert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  33     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1984-12-03     Completed Date:  1984-12-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1003-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Apolipoprotein A-I
Apolipoprotein A-II
Apolipoproteins A / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Dietary Carbohydrates / pharmacology*
Dietary Fats / pharmacology*
Humans
Lipids / blood*
Lipolysis
Lipoproteins / blood*
Male
Physical Endurance*
Running
Triglycerides / blood
Grant Support
ID/Acronym/Agency:
HL01003/HL/NHLBI NIH HHS; HL28467/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Apolipoprotein A-II; 0/Apolipoproteins A; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Lipids; 0/Lipoproteins; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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