| The effects of hemodynamic force on embryonic development. | |
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MedLine Citation:
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PMID: 20374481 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blood vessels have long been known to respond to hemodynamic force, and several mechanotransduction pathways have been identified. However, only recently have we begun to understand the effects of hemodynamic force on embryonic development. In this review, we will discuss specific examples illustrating the role of hemodynamic force during the development of the embryo, with particular focus on the development of the vascular system and the morphogenesis of the heart. We will also discuss the important functions served by mechanotransduction and hemodynamic force during placentation, as well as in regulating the maintenance and division of embryonic, hematopoietic, neural, and mesenchymal stem cells. Pathological misregulation of mechanosensitive pathways during pregnancy and embryonic development may contribute to the occurrence of cardiovascular birth defects, as well as to a variety of other diseases, including preeclampsia. Thus, there is a need for future studies focusing on better understanding the physiological effects of hemodynamic force during embryonic development and their role in the pathogenesis of disease. |
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Authors:
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James C Culver; Mary E Dickinson |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Microcirculation (New York, N.Y. : 1994) Volume: 17 ISSN: 1549-8719 ISO Abbreviation: Microcirculation Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-08 Completed Date: 2010-06-29 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9434935 Medline TA: Microcirculation Country: United States |
Other Details:
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Languages: eng Pagination: 164-78 Citation Subset: IM |
Affiliation:
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Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Thoracic / embryology, physiology Blood Vessels / embryology, physiology Embryo Implantation / physiology Embryonic Development / physiology* Embryonic Stem Cells / physiology Endothelial Cells / physiology Female Fetal Heart / embryology, physiology Hematopoiesis Hemodynamics / physiology* Humans Mechanotransduction, Cellular / physiology Models, Cardiovascular Placenta / blood supply, growth & development Pregnancy Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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EB005173/EB/NIBIB NIH HHS; EB007076/EB/NIBIB NIH HHS; HL077187/HL/NHLBI NIH HHS; P20 EB007076-03/EB/NIBIB NIH HHS; R01 EB005173-05/EB/NIBIB NIH HHS; R01 HL077187-03/HL/NHLBI NIH HHS |
| Comments/Corrections | |
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