| The effects of handling on antibody production, mitogen responses, spleen cell number, and lymphocyte subpopulations. | |
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MedLine Citation:
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PMID: 2362549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of a simple psychosocial manipulation, handling, on immune function in BALB/c.ByJ mice were studied. Handling for two minutes/day prior to immunization was shown to be associated with a decreased primary IgG antibody response to the protein antigen keyhole limpet hemocyanin. Handling was also associated with decreased T cell proliferative responses to Concanavalin A. No reliable changes in spleen cell number or lymphocyte subsets were found. These findings demonstrate that simply picking up an animal results in modulation of the immune response. These data are also of interest for their obvious methodological implications. |
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Authors:
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J Moynihan; G Brenner; D Koota; S Breneman; N Conen; R Ader |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Life sciences Volume: 46 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1990 |
Date Detail:
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Created Date: 1990-08-07 Completed Date: 1990-08-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1937-44 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Rochester Medical Center, NY 14642. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Animals, Laboratory / immunology Female Flow Cytometry Handling (Psychology)* Immunization Immunoglobulin G / biosynthesis* Leukocyte Count / veterinary Lymphocyte Activation Lymphocytes / immunology* Mice Mice, Inbred BALB C / immunology* Random Allocation Spleen / cytology, immunology T-Lymphocytes / immunology |
| Grant Support | |
ID/Acronym/Agency:
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5T35 HL07496/HL/NHLBI NIH HHS; MH45681/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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