Document Detail


The effects of haloperidol and amphetamine on ascorbic acid and uric acid in caudate and nucleus accumbens of rats as measured by voltammetry in vivo.
MedLine Citation:
PMID:  2402194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of haloperidol (0.1 mg/kg) to reduce the amphetamine-induced (2 and 5 mg/kg) increase in ascorbic and uric acid in anterior caudate and in nucleus accumbens was tested using voltammetry in vivo. In both areas, haloperidol reduced the amphetamine-induced increase in uric acid. In both areas, haloperidol only marginally affected the amphetamine-induced increase in ascorbic acid. Amphetamine-induced increases in uric acid were more nearly dose-related than changes in ascorbic acid. Of the two compounds, uric acid seems more likely to be associated with dopamine.
Authors:
K Mueller
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  47     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1990  
Date Detail:
Created Date:  1990-10-23     Completed Date:  1990-10-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  735-42     Citation Subset:  IM    
Affiliation:
Dept. of Psychology, Texas Christian University, Fort Worth 76129.
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MeSH Terms
Descriptor/Qualifier:
Amphetamine / pharmacology*
Analysis of Variance
Animals
Ascorbic Acid / metabolism*
Caudate Nucleus / drug effects*,  metabolism
Electrophysiology
Haloperidol / pharmacology*
Male
Nucleus Accumbens / drug effects*,  metabolism
Rats
Rats, Inbred Strains
Septal Nuclei / drug effects*
Uric Acid / metabolism*
Grant Support
ID/Acronym/Agency:
R01NS25726/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
300-62-9/Amphetamine; 50-81-7/Ascorbic Acid; 52-86-8/Haloperidol; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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